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Brain Cancer Study Opens at Overlook Medical Center - One of Four Sites in Country

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Kurt Jaeckle, MD, co-director of the Gerald J. Glasser Brain Tumor Center at Overlook Medical Center, and medical director of the Atlantic Center for Research, is leading a phase III study of novel drug VAL-083, which has already shown promise in Glioblastoma and other cancers.  The study is for patients whose glioblastoma multiforme or gliosarcoma has progressed during or after treatment with the standard of care chemo-radiation therapy. Other study locations are: Kaiser Permanente Los Angeles Medical Center; University of California, San Francisco; and Dent Neurosciences Research Center, Amherst, NY.

“Glioblastoma is very difficult to treat, and I am encouraged by previously reported results with VAL-083,” said Dr. Jaeckle.  “I am also happy that some of the most innovative pharmaceutical companies are looking to Atlantic Health System when they seek to test new types of treatments for brain tumors. The availability of this and other neuro-oncology clinical trials provides a benefit to our patients, and gives me hope for the future.”

Glioblastoma is the most common and most aggressive type of brain cancer, with typical survival of 14-20 months for newly diagnosed patients.  Standard treatment includes surgery to remove as much of the tumor as is safely possible, followed by radiation therapy and chemotherapy with temozolomide.  Nearly all glioblastoma patients will relapse.  Gliosarcoma, which is also being studied in this clinical trial, is a rare and equally aggressive form of glioblastoma. 

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VAL-083 is a first-in-class small molecule chemotherapy drug.  This means that the molecular structure of VAL-083 is not similar in chemical structure (an analogue) or derivative of other small molecule chemotherapeutics approved for the treatment of cancer.  VAL-083 is unique in that it has been shown to overcome cancer cells’ resistance to MGMT, a DNA-repair mechanism that causes recurrent glioblastoma to resist treatment with temozolomide.  Many glioblastoma tumors express large amounts of MGMT, making them difficult to treat with currently available chemotherapies.

According to DelMar Pharmaceuticals, VAL-083 has been assessed in 42 Phase I and Phase II clinical trials sponsored by the National Cancer Institute as a treatment against various cancers. Published pre-clinical and clinical data suggest that VAL-083 may be active against a range of tumor types, including lung, brain, cervical, ovarian tumors and hematologic (blood) cancers.  Earlier clinical trials have shown that VAL-083 is comparable or superior to other chemotherapies in treating glioblastoma.

To learn more about study inclusion and exclusion criteria, go to the Atlantic Center for Research: research.atlantichealth.org/VAL_083.

About the Gerald J. Glasser Brain Tumor Center

Specialists at the Gerald J. Glasser Brain Tumor Center treat a variety of brain tumors and related conditions, including acoustic neuromas and schwannomas; anaplastic astrocytomas, oligodendrogliomas and low-grade gliomas; brain, epidural and leptomeningeal metastases; ependymomas; glioblastomas; low-grade astrocytomas; lymphomas; meningiomas; medulloblastomas; peripheral nerve, pineal and pituitary tumors; rare glial and neuronal tumors; sarcomas; and spinal cord tumors. The center features a multidisciplinary panel of experts who specialize in neurosurgery, skull base surgery, neuroradiology, radiation oncology, neuro-oncology, medical oncology, neurology, neuropathology and social work. Overlook Medical Center also has the largest CyberKnife® program in the tri-state area for the treatment of brain tumors. The brain tumor center recently moved into its own space on the main level of Overlook Medical Center, in order to foster an optimal, convenient patient-centered experience.

Dr. Jaeckle sees patients at the Gerald J. Glasser Brain Tumor Center of Overlook Medical Center’s Atlantic Neuroscience Institute and Carol G. Simon Cancer Center, 99 Beauvoir Avenue, Summit, NJ. He and other members of the Gerald J. Glasser Brain Tumor Center can be reached at (908) 516-2941. For more information on this clinical trial or other studies, please call the Atlantic Center for Research at (973) 971-5235.

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Berkeley Heights

2018 Gov. Livingston Highlander Softball Clinic Set for March 19

February 20, 2018

Come join and learn from the 2017 Union County Softball Champion Gov. Livingston coaches and varsity players on Monday, March 19, 2018 from 6:30 to 8 p.m.

Activities will include the following fastpitch softball skills:

Batting Techniques
Throwing Mechanics
Fielding
Base Running

Who: Children grades 1-7 of any skill level or ability

Where: Gov. Livingston High School, 175 ...

Mike Zuko at Salem Roadhouse Cafe

Raised on a diet of The Beatles, Buddy Holly and The Doors, Michael Zuko was exposed first hand to the thrilling music of the legendary 70s NYC club scene. Zuko and the band show a skilled singer-songwriter who is backed by solid musical talent, bringing original, fresh and intelligent lyrics to the stage. A true entertainer, Mike engages the audience fully and leaves them wanting more. Mike and ...

German Language School of Morris County Raises $1,000 for Market Street Mission

February, the month of all things red and romantic with red, hearts, roses, and chocolates, is also a time to show our love of friends and community. Students from the German Language School of Morris County (www.njlearnsgerman.org and www.glsmc.org), took that lesson to heart and raised $1,000 for The Market Street Mission (www.marketstreet.org), a Morristown haven for the needy for more than ...

Kick Off for the Relay for Life of Berkeley Heights, Mountainside, New Providence & Summit 

BERKELEY HEIGHTS, NJ - There will be a Kick Off for Relay for Life on Thursday, March 1st. It will be held at the Gov. Livingston High School Cafeteria at 7pm.  The theme of Kick Off is Back TO GL - we envision a future that is cancer free. Everything you need to know about Relay for Life will be presented in an interactive setting. Relay ...

We Need More Women Like Colleen Mahr in Municipal, County and State Government

February 19, 2018

Dear Editor:

I’m proud to support Colleen Mahr for Chair of the Union County Democratic Committee  (UCDC) and am encouraging my Scotch Plains peers to join me.

I was a first time candidate wanting to make a difference in my hometown of Scotch Plains, when Mayor Mahr of neighboring Fanwood stepped in to help me campaign and win my election to be Councilwoman three years ago.

Democratic Party Would Be Making a Big Mistake by Not Recognizing Colleen Mahr's Talents

Dear Editor:

Mayor Colleen Mahr has been a valuable friend to the Township of Cranford. Whether it’s offering advice and assistance during devastating flood cleanup, supporting the Mayor's Council on the Rahway River, or her insight and assistance in meeting our affordable housing obligations, Mayor Mahr is always there for Cranford.

Colleen’s fairness and integrity is ...

Colleen Mahr Is The Leader Our Party Needs

Dear Editor:

My name is Patti Murgo. I am Committeewoman in Linden’s Eighth Ward. I am a life-long  DEMOCRAT, a party activist, and a believer in what being a democrat stands for. Last week, I received a piece of literature from our municipal chairman, Nick Scutari, regarding his “plans” for the County Democratic Party if he is elected county chairman.

Mr.

Chatham Borough Police Chief Crosson has Retired; Captain Gibbons is Acting Commander

February 12, 2018

CHATHAM, NJ - Phil Crosson Jr., who has been a member of the Chatham Borough Police Department since 1992, retired from his position as the police chief on Feb. 1.

"It came on pretty quickly," Crosson said when reached by phone on Sunday. "I was on vacation for six weeks and I bought a business. I came back for one day and retired."

According to Crosson, ...

‘Reefer Madness’ Comes to Chatham Borough Council; Cannabis Advocates Make Pitch for Chatham Marijuana Shop

February 14, 2018

CHATHAM, NJ - A group of pro-cannabis activists came to the Borough of Chatham Council meeting on Monday night and used the public commentary portion of the meeting to ask the council to support a marijuana dispensary in town.

The advocates, who say they have attended more than 80 town meetings to inform about the benefits of medical cannabis, mentioned the 1936 movie "Reefer ...

Upcoming Events

Tue, February 20

Scherman Hoffman Wildlife Sanctuary, Bernardsville

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Next Level Business Planning

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Fri, February 23

Scherman Hoffman Wildlife Sanctuary, Bernardsville

NJ Audubon: Volunteer Art Show!

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Invest Like a Tortoise -- Not Like a Hare

Aesop’s “The Tortoise and the Hare” is a perfect metaphor for the way people go about investing their money. As you recall in the fable, the hare brags about his ability to beat the tortoise and is overly confident about winning. In the investment world, the hare is someone who thinks he or she is great at selecting “winners” and avoiding “losers.” The ...