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Atlantic Health System Cancer Care First in World to Begin Clinical Trial of Novel Virus-Based Immunotherapy for Late-Stage Melanoma; First Patient Enrolled


Dr. Eric Whitman Leads Study of Experimental Drug That Uses Cold Virus to Disable Cancer Cells in Patients Who Have Not Responded to Other Treatments

Morristown, NJ Atlantic Health System Cancer Care is the first oncology institution in the world to sign on to, and to enroll the first patient in, a multicenter Phase IIa clinical trial of OBP-301 (Telomelysin®), a virus-based immunotherapy for late-stage melanoma that has not responded to other treatments. 

This leading-edge experimental therapy, which is under development by Japanese biotechnology company Oncolys BioPharma, uses the common cold virus to modify a gene that can selectively replicate in, and destroy, cancer cells. The study protocol was approved by the U.S. Food and Drug Administration (FDA) in June.

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The clinical trial is being led locally by Eric D. Whitman, MD, FACS, medical director of Atlantic Health System Cancer Care and director of the Carol G. Simon Cancer Center’s Atlantic Melanoma Center at Morristown Medical Center and Overlook Medical Center.

“This targeted immunotherapy holds great promise for improving survival rates in patients with unresectable and metastatic melanoma,” said Dr. Whitman.  “We are proud to have been chosen as the first site for this leading edge clinical trial, and happy to be able to offer a wide range of the latest established and experimental treatments to our patients.”

Melanoma, the most serious form of skin cancer, affects more than 50,000 people each year. Although the chances of having melanoma increase with age, the number of cases among young adults is rising every year. Melanoma can have serious health consequences and may even be fatal.

The OBP-301 trial is a multicenter, Phase IIa study to evaluate how melanoma tumors respond to injection of this drug in patients with Stage III and Stage IV melanoma -- that is, to determine how much the drug shrinks or destroys tumors after it is injected into them.  The study, which will also look at potential side effects, is “open label,” meaning that all participants in the study will receive OBP-301. 

OBP-301 is a type of virus known as an adenovirus. Adenoviruses are common in nature and when they multiply in normal human cells they may cause infections that result in symptoms like those of the common cold or the flu.  OBP-301 has been genetically changed from the original virus to reproduce in target cancer cells that are emitting a certain signal. As a result of this reproduction, OBP-301 is believed to burst and kill tumor cells.

Study participants will receive multiple injections into their tumors over a period of several weeks.  Blood tests will be done to evaluate the level of virus in patients’ systems, and for immune response monitoring. Dr. Whitman and colleagues will also evaluate how long it takes to get a response and how long responses last, as well as overall survival and progression-free survival rates.

In preclinical studies, Oncolys demonstrated OBP-301’s anti-tumor activity in various types of cancer cells.  A Phase I clinical trial in the U.S. demonstrated the drug’s safety, and showed that it shrank tumors in a majority of study participants, who had a variety of solid tumors.  Additional studies of the drug have been completed, or are underway, in Japan, Korea and Taiwan.

The Atlantic Melanoma Center, a clinical and research center of excellence, is an internationally-recognized program. The center’s multidisciplinary approach-- combining the expertise of board-certified surgeons, medical oncologists, pathologists, radiation oncologists and nurses – treats all forms of melanoma, including those in the skin, mucous membranes and eyes.  Patients receive the latest medical treatments, and when needed, melanoma surgery is also available. 

For more information on the OBP-301 clinical trial or other studies, please call the Atlantic Melanoma Center at 973-971-7111.  

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East Hanover/Florham Park

Outstanding Citizens To Be Honored at the Boy Scouts of America 23rd Annual Morris County Lifetime Achievement Awards Dinner

March 17, 2018

WHIPPANY, NJ - Boy Scouts of America, Patriots’ Path Council will be honoring local community members at the Boy Scouts of America 23rd Annual Morris County Lifetime Achievement Awards Dinner to be held on the evening of April 19 at The Hanover Marriott in Whippany at 6:30 pm.  This year’s honorees are Reynaldo Caudillo, Bruce Jones, Michael Lupton, Ron Morano, Lou ...

Belmar/Lake Como St. Patrick’s Day Parade: Where Everyone is Irish for the Day

March 5, 2018

BELMAR/LAKE COMO, NJ — As the sun played hide and seek with the clouds yesterday afternoon, the Belmar/Lake Como St. Patrick's Day Parade marched down Main Street — in step with Irish tradition and community spirit.

As the sun played hide and seek with the clouds yesterday afternoon, the Belmar/Lake Como St. Patrick's Day Parade marched down Main Street — in step with ...

Recipe of the Week: Citrus Marinated Steak


1/3 cup soy sauce
1/3 lemon juice
½ cup olive oil
¼ cup Worcestershire Sauce
1 TBS garlic, minced
1 tsp. black pepper
½ tsp. salt
½ tsp. thyme & 3-4 sprigs
Juice of one blood orange
1 ½ lb. steak

To make the marinade, in a small bowl, whisk together all the ingredients.  Using a plastic storage bag that closes ...

Sparta High School Students Create Donate Life Club

March 20, 2018

SPARTA, NJ – Sparta High School students held their inaugural meeting of the Donate Life Club on Wednesday, March 14. Minutes after the walk out in solidarity with Parkland school shooting victims, thirty students met in a classroom during lunch to hear from the NJ Sharing Network about organ donation.

Many of the students were classmates of Isak Anderson, a boy who passed away suddenly ...


AtlantiCast: Episode 13

On this episode of AtlantiCast, new clinical studies in the fields of cardiology and immunotherapy, national and statewide recognitions for Atlantic Health System medical centers and the inaugural AtlantiCast Collab Challenge!


Upcoming Events


Wed, March 21, 8:30 AM

St. Vincent Martyr School, Madison

Open House for Preschool, Kindergarten & First ...



Wed, March 21, 6:00 PM

Barnabas Health Ambulatory Care Center, Conference Room A/B, First Floor, Livingston

Colon Cancer Screening Education Program at Saint ...

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Wed, March 21, 7:00 PM

Livingston Public Library, Livingston

Empowering Women to Take Control of Their ...

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Frank J Smith School Hosts Scholastic Book Fair March 21-22

March 20, 2018

EAST HANOVER, N.J.- The East Hanover PTA is sponsoring The Scholastic Book Fair at Frank J Smith School this week, Wednesday and Thursday. Opportunities are still available to volunteer and donations will go directly to books for the school as all donations will be matched by Scholastic. Shopping on line is also available by clicking here. 

Joey Bella Memorial Fund, Inc. Band Beer Beefsteak

March 19, 2018

Joey Bella Memorial Fund, Inc. Band Beer Beefsteak  On-line Ticket Sales 

The 29th Annual Band Beer Beefsteak will be held on Tuesday, July 3, 2018 "under the tent" at Gardner Field, Savage Road and Route 46W, Denville.  Tickets are $60 per person and include an all-you-can-eat Beefsteak Dinner served by Giresi Caterers and 15+ microbrew beers.  Entertainment will ...