Danny Federici played the organ, glockenspiel, and accordion as a founding member for Bruce Springsteen's E Street Band. Federici's organ sounds are considered to be an important feature in the E Street sound, and took on a more prominent role in the hit "Hungry Heart". He attended Hunterdon Central High School. 

During the long time the E Street Band was inactive during the 1990s, Federici recorded a solo album of jazz instrumentals called Flemington, as a tribute to his hometown. 

In 2007, Federici took a leave of absence from Springsteen and the E Street Band's ongoing Magic Tour to pursue treatment for melanoma. Springsteen stated at the time: “Danny is one of the pillars of our sound and has played beside me as a great friend for more than 40 years. We all eagerly await his healthy and speedy return.”  He passed away in 2008 at the Memorial Sloan-Kettering Cancer Center in New York City, having suffered for three years with melanoma. 

In 2014, Federici was posthumously inducted into the Rock and Roll Hall of Fame as a member of the E Street Band.