Jessica Vosk was raised in Clinton, and attended North Hunterdon High School. Her big break came in 2009 when she was cast as a vocalist for the live concert Kristina written by Benny Andersson and Björn Ulvaeus of ABBA and performed at Carnegie Hall and at London's Royal Albert Hall.

Jessica made her Broadway debut in Bridges of Madison County, where she made her principal debut as Marian. She also was an understudy for the role of Chiara. From The Bridges of Madison County she went to Finding Neverland, in which she was in the original Broadway production playing the role of Miss Bassett.

She then played Fruma Sarah in the Broadway Revival of Fiddler on the Roof, and  was an understudy for Golde/Yente.

But she is best known for her performance as the lead role of Elphaba in Wicked, which she played on Broadway at the Gershwin Theatre during a period that included the show's 15th Anniversary.