Sarah Schneider graduated from North Hunterdon High School in 2001. She got her start in entertainment as a writer and actress for the comedy website CollegeHumor before becoming a writer for the television sketch comedy series Saturday Night Live. As part of the CollegeHumor staff, she starred as a fictionalized version of herself in the short-lived television series The CollegeHumor Show (2009) and web series including Hardly Working and Full Benefits.

Schneider became a writer for Saturday Night Live and her musical sketch "(Do It On My) Twin Bed" was her first big SNL hit with fellow writer Chris Kelly.[She and Kelly also wrote "Hometown Tourism Ad" since joining SNL in 2011, and "Christmas Spectacular." Vulture named Schneider and Kelly onto their list in 2014 of the 50 comedians to watch. 

In August 2016, SNL promoted Schneider and Kelly to co-head writers of the 42nd season of the show. She's been nominated several times for Emmy Awards for "Outstanding Writing for a Variety Special." Most recently Schneider has created The Other Two, an American comedy television series which premiered on Comedy Central.