Press Releases

Brain Cancer Study Opens at Overlook Medical Center - One of Four Sites in Country

84c7598a938691beaecb_Dr._Kurt_Jaeckle_preferred_2017.jpg
84c7598a938691beaecb_Dr._Kurt_Jaeckle_preferred_2017.jpg

Kurt Jaeckle, MD, co-director of the Gerald J. Glasser Brain Tumor Center at Overlook Medical Center, and medical director of the Atlantic Center for Research, is leading a phase III study of novel drug VAL-083, which has already shown promise in Glioblastoma and other cancers.  The study is for patients whose glioblastoma multiforme or gliosarcoma has progressed during or after treatment with the standard of care chemo-radiation therapy. Other study locations are: Kaiser Permanente Los Angeles Medical Center; University of California, San Francisco; and Dent Neurosciences Research Center, Amherst, NY.

“Glioblastoma is very difficult to treat, and I am encouraged by previously reported results with VAL-083,” said Dr. Jaeckle.  “I am also happy that some of the most innovative pharmaceutical companies are looking to Atlantic Health System when they seek to test new types of treatments for brain tumors. The availability of this and other neuro-oncology clinical trials provides a benefit to our patients, and gives me hope for the future.”

Glioblastoma is the most common and most aggressive type of brain cancer, with typical survival of 14-20 months for newly diagnosed patients.  Standard treatment includes surgery to remove as much of the tumor as is safely possible, followed by radiation therapy and chemotherapy with temozolomide.  Nearly all glioblastoma patients will relapse.  Gliosarcoma, which is also being studied in this clinical trial, is a rare and equally aggressive form of glioblastoma. 

Sign Up for E-News

VAL-083 is a first-in-class small molecule chemotherapy drug.  This means that the molecular structure of VAL-083 is not similar in chemical structure (an analogue) or derivative of other small molecule chemotherapeutics approved for the treatment of cancer.  VAL-083 is unique in that it has been shown to overcome cancer cells’ resistance to MGMT, a DNA-repair mechanism that causes recurrent glioblastoma to resist treatment with temozolomide.  Many glioblastoma tumors express large amounts of MGMT, making them difficult to treat with currently available chemotherapies.

According to DelMar Pharmaceuticals, VAL-083 has been assessed in 42 Phase I and Phase II clinical trials sponsored by the National Cancer Institute as a treatment against various cancers. Published pre-clinical and clinical data suggest that VAL-083 may be active against a range of tumor types, including lung, brain, cervical, ovarian tumors and hematologic (blood) cancers.  Earlier clinical trials have shown that VAL-083 is comparable or superior to other chemotherapies in treating glioblastoma.

To learn more about study inclusion and exclusion criteria, go to the Atlantic Center for Research: research.atlantichealth.org/VAL_083.

About the Gerald J. Glasser Brain Tumor Center

Specialists at the Gerald J. Glasser Brain Tumor Center treat a variety of brain tumors and related conditions, including acoustic neuromas and schwannomas; anaplastic astrocytomas, oligodendrogliomas and low-grade gliomas; brain, epidural and leptomeningeal metastases; ependymomas; glioblastomas; low-grade astrocytomas; lymphomas; meningiomas; medulloblastomas; peripheral nerve, pineal and pituitary tumors; rare glial and neuronal tumors; sarcomas; and spinal cord tumors. The center features a multidisciplinary panel of experts who specialize in neurosurgery, skull base surgery, neuroradiology, radiation oncology, neuro-oncology, medical oncology, neurology, neuropathology and social work. Overlook Medical Center also has the largest CyberKnife® program in the tri-state area for the treatment of brain tumors. The brain tumor center recently moved into its own space on the main level of Overlook Medical Center, in order to foster an optimal, convenient patient-centered experience.

Dr. Jaeckle sees patients at the Gerald J. Glasser Brain Tumor Center of Overlook Medical Center’s Atlantic Neuroscience Institute and Carol G. Simon Cancer Center, 99 Beauvoir Avenue, Summit, NJ. He and other members of the Gerald J. Glasser Brain Tumor Center can be reached at (908) 516-2941. For more information on this clinical trial or other studies, please call the Atlantic Center for Research at (973) 971-5235.

TAP Into Another Town's News:

You May Also Be Interested In

Sign Up for E-News

Franklin Township

Franklin Township: St. Matthias Carnival Postponed Saturday, Volunteers Still Need for Sunday

May 19, 2018

SOMERSET, NJ -The St. Matthias Carnival will open at 6 PM today, instead of its regularly scheduled start time of 2 PM, according to its website.

"Check back around 4:30 to see if there are other changes," the website reads. 

Volunteers are also still needed for Sunday. Sign up to Volunteer by clicking HERE.

Sunday, May 20, 2 PM to 9 PM 
* Same ...

Fallout Continues from Lawsuit Against Mountainside; Police Chief on Administrative Leave

May 19, 2018

MOUNTAINSIDE, NJ – Police Chief Allan Attanasio is the latest member of the police department to suffer repercussions from a complaint filed against the borough on May 11.  Attanasio, who is not named as a defendant in the lawsuit, was “placed on administrative leave,” on Thursday by Borough Administrator and former Police Chief James Debbie, said  Lt. Joseph ...

Video Shows School Board Member In Altercation With Police at Traffic Stop in South Orange

SOUTH ORANGE, NJ - South Orange Maplewood School Board Member Stephanie Lawson-Muhammad got into an altercation with a South Orange police officer who stopped her for speeding last month, in which she used profanity, complained when she was issued a ticket and called South Orange Police Chief Kyle Kroll “a skinhead cop.”

Lawson-Muhammad also appeared to suggest that she would ...

Three Bloomfield Teens Are Missing, Police Seek Community Assistance to Locate Them (FOUND)

BLOOMFIELD, NJ - Bloomfield Department of Public Safety Director Samuel DeMaio confirmed that three missing teenagers have been found safe at a McDonald's restaurant in Pennsylvania.

Original article:

The Bloomfield Police Department is asking for the public's assistance to locate three teenagers who went missing this week. One of the parents reports that a large sum of money is ...

Police Investigate Rabbit "Tale"

SOUTH PLAINFIELD, NJ – Local cops are investigating an incident of ‘theft by deception’ involving the Plainfield Animal Hospital. 

According to the incident report filed by Officer Justin Melanson and obtained by TAPinto, residents of South Plainfield took their pet rabbit to the Park Avenue animal hospital on April 4 to be euthanized due to advanced ...

Student found dead outside Rutgers dorm, 2nd in one week

NEW BRUNSWICK - For the second time in less than a week, a Rutgers University student has been found dead outside a dorm.

Kyle Gotchel, a sophomore business major, was found outside Hardenbergh Hall on Monday, university officials said in a statement today.

“I am saddened to share the news that our student, Kyle Gotchel, died yesterday,”  Chancellor Deb Dutta said in a ...

Three stabbed in late night assault at party

NEW BRUNSWICK - Three people were stabbed following a fight at a party late Saturday on Delafield Street between Bristol and Courtland streets, Rutgers police said in an alert sent out today.

The assault, which was not on the Rutgers University campus, occurred about 11:45 p.m., police said.

They said the victims are not affiliated with the university. All three victims reported being ...

Fallout Continues from Lawsuit Against Mountainside; Police Chief on Administrative Leave

May 19, 2018

MOUNTAINSIDE, NJ – Police Chief Allan Attanasio is the latest member of the police department to suffer repercussions from a complaint filed against the borough on May 11.  Attanasio, who is not named as a defendant in the lawsuit, was “placed on administrative leave,” on Thursday by Borough Administrator and former Police Chief James Debbie, said  Lt. Joseph ...

Video Shows School Board Member In Altercation With Police at Traffic Stop in South Orange

SOUTH ORANGE, NJ - South Orange Maplewood School Board Member Stephanie Lawson-Muhammad got into an altercation with a South Orange police officer who stopped her for speeding last month, in which she used profanity, complained when she was issued a ticket and called South Orange Police Chief Kyle Kroll “a skinhead cop.”

Lawson-Muhammad also appeared to suggest that she would ...

Three Bloomfield Teens Are Missing, Police Seek Community Assistance to Locate Them (FOUND)

BLOOMFIELD, NJ - Bloomfield Department of Public Safety Director Samuel DeMaio confirmed that three missing teenagers have been found safe at a McDonald's restaurant in Pennsylvania.

Original article:

The Bloomfield Police Department is asking for the public's assistance to locate three teenagers who went missing this week. One of the parents reports that a large sum of money is ...

Somerville’s Girls Night Out: Prepare to be Pampered, Expect to be Pleased

May 17, 2018

SOMERVILLE, NJ  - Girls' Night Out in Downtown Somerville might start out a little bit soggy, but the Accu-Weather  forecast for late Thursday afternoon and early evening is cause for optimism – 50 percent chance of rain in the afternoon, maybe ending by  6 p.m.

Regardless,  the long-awaited event is advertised as a rain or shine affair, and there will be more ...

Franklin Township: Hillsborough Teen Prevails in Chess Match Against Somerset Freeholder Levine

ROCKY HILL, NJ – Somerset County Freeholder Brian Levine had his hands full as he matched wits with 10 young chess players in a simultaneous tournament at the Mary Jacobs Memorial Library.May 14.

Levine’s opponents, ages 6-18, proved to be formidable opponents, with 7-year-old Grace Liang stumping Levine several times before he prevailed.

Some matches took as long as three ...

Somerville Honors' Student Speaks at RVCC Graduation; 1,300 Receive Degrees

BRANCHBURG, NJ - Raritan Valley Community College awarded associate degrees and certificates to more than 1,300 graduates at its commencement, Saturday, May 12, including Somerville resident Barbara Kania, an Honors College student who introduced commencement speaker Judge Paul W. Armstrong.

Kania is a Pre-Medical Professional major who is the founder and president of RVCC’s Pre-Medicine ...

Somerville’s Girls Night Out: Prepare to be Pampered, Expect to be Pleased

May 17, 2018

SOMERVILLE, NJ  - Girls' Night Out in Downtown Somerville might start out a little bit soggy, but the Accu-Weather  forecast for late Thursday afternoon and early evening is cause for optimism – 50 percent chance of rain in the afternoon, maybe ending by  6 p.m.

Regardless,  the long-awaited event is advertised as a rain or shine affair, and there will be more ...

Franklin Township: Hillsborough Teen Prevails in Chess Match Against Somerset Freeholder Levine

ROCKY HILL, NJ – Somerset County Freeholder Brian Levine had his hands full as he matched wits with 10 young chess players in a simultaneous tournament at the Mary Jacobs Memorial Library.May 14.

Levine’s opponents, ages 6-18, proved to be formidable opponents, with 7-year-old Grace Liang stumping Levine several times before he prevailed.

Some matches took as long as three ...

SURVIVING A STROKE: Quick Medical Response Gives Mom Her Life Back

Carotid artery dissection. It’s one of the most common causes of stroke in younger adults.

And while you might not associate the word “stroke” with younger patients, the condition – if not treated immediately – could lead to paralysis and even death.

Lindsey Singh can attest to the importance of immediacy. The 31-year-old mother of two from Flanders experienced ...

AtlantiCast

AtlantiCast: Episode 15

On this week’s AtlantiCast, learn some important tips for controlling and avoiding diabetes from an Atlantic Health System expert, see how Atlantic Health is advancing cutting-edge research, hear what’s being done to keep health care environmentally friendly and much more!