Press Releases

Science Research Wins National Distinction

258708565e69a5892b58_DSC_3689.JPG
Krishan Kania, right, and  Alexander Nie – won semifinalists honors in the national Intel Science Talent Search. Credits: LPS
258708565e69a5892b58_DSC_3689.JPG
Two Livingston High School seniors – Krishan Kania and  Alexander Nie – won semifinalists honors in the national Intel Science Talent Search (STS) for their research projects that could optimize the healing process and lead to better cancer diagnosis.
 
Intel is the nation's oldest competition for teenage researchers, bringing together the best and brightest young scientific minds. Kania and Nie will receive a $1,000 award from the Intel Foundation. LHS will also receive an additional $2,000 from the foundation for the achievements of its two semi-finalists.  
 
The LHS students join a distinguished list of student researchers. Alumni of STS have made extraordinary contributions to science and hold more than 100 of the world's most coveted science and math honors, including seven Nobel Prizes and four National Medals of Science.
 
Kania’s project, titled, “Making an IMPACT: Advancing the Computation of Next-Generation Sequencing Data,” involved the creation of a computer program that has now been packaged into a larger software called "IMPACT" (Integrated Mutation Profiling of Actionable Cancer Targets).  The project has been published in three academic journals in the field of bioinformatics.  In addition to Intel, Kana was named a semi-finalist in the Siemens Competition in October.

"Traditionally, we think of cancer in terms of its location: lung, pancreas, etc. However, with the quantitative background of the scientists involved in The Cancer Genome Atlas and my mentors at the Berger lab in Sloan-Kettering, cancer is starting to be described in terms of genomics, on the resolution of DNA,” Kania explained. “IMPACT (Integrated Mutation Profiling of Actionable Cancer Targets) refers to one assay that has adopted DNA sequencing technology to better diagnosis cancer patients.”
 
“Each sequencing assay differs from one another due to a number of methods generally categorized as library preparation, sequencing, and data analysis.  Projects such as The Cancer Genome Atlas have developed assays designed to study common cancer types from high profile tissue,” he said. “IMPACT, however, recognizes that truly personalized cancer medicine will come from assays that can make strong conclusions, but with lower quality, and more clinically feasible, tissue specimens.  Experimental techniques of IMPACT have addressed this well, but there is still much to be resolved computationally.  For personalized cancer medicine, investigators will need a computational methodology that promises speed and confidence, two important necessities for effective patient care.”
 
“With this in mind, I developed a computer program, which has been implemented in assays such as IMPACT, to more efficiently analyze next-generation sequencing data from cancer tissues.  The results of this project can be best summarized as a program that performs 568 times as fast as the traditional methodologies, while presenting more informative and developed metrics.  When implemented into IMPACT, this program is part of the collective effort to produce better outcomes in cancer patients, and make cancer a more manageable disease."
 
Nie examined “Gelatin Hydrogels as a Cellular Scaffold: The Effect of Glucose on Gel Structure and Fibroblast Behavior.”

“My project studied the effects of glucose, a simple sugar, on hydrogels made of gelatin, a material derived from animal tissue,” he explained. “Specifically, my project analyzed the gel's hardness, surface features, and ability to promote cell growth and migration. Overall, I found that optimal hydrogels have glucose concentrations near normal blood sugar levels (2mg/mL). At 2mg/ml, the sugar not only strengthens the gel, but also promotes cell growth and migration. Therefore, hydrogels used in cell delivery should mimic the body's blood sugar levels to optimize the healing process.”

“We at Livingston High School are very proud of both Kris and Alex.  Both of these young men continue to challenge themselves with rigorous schedules and participation in numerous science clubs, competitions and summer experiences,” said Brian Carey, Chairman of the LHS Science Department and Director of Science Research.

“Kris and Alex both sought out opportunities to further their science and research knowledge and skills this past summer and their hard work has clearly paid off,” Carey said.

The Intel STS recognizes 300 students and their schools as semifinalists each year. From that select pool, 40 finalists are then invited to Washington, DC, undergo final judging, display their work to the public, meet with notable scientists, and compete for the top award of $100,000.

TAP Into Another Town's News:

You May Also Be Interested In

Sign Up for E-News

Livingston

Register Now to Save Over $200 at West Essex Cheer and Tumble Academy

July 22, 2018

WEST ORANGE, NJ - West Essex Cheer & Tumble Academy is now offering $75 off per month for your first three months. Register now at wecheeracademy.com/explorer-academy, use Code TAP to receive $75 off per month for your first three months. 

Children who take the after-school classes also qualify to receive a $40 per month discount on any of the gyms All ...

Save $2.50 on Next Visit to Livingston Car Wash

LIVINGSTON, NJ — Drivers can save $2.50 the next time they get their vehicle cleaned at Livingston Car Wash.

Come to Livingston Car Wash at 111 E. Mt. Pleasant Avenue for a car wash and $2.50 will be discounted from the regular price.

Upcoming Events

Carousel_image_79d791602b5680d23c85_original

Tue, July 24, 7:00 PM

Livingston Public Library, Livingston

Meet the Author: Lucy Tan

Arts & Entertainment

Carousel_image_0e3e9edb72bd75ae1c80_bobbyvalli_par440_3_dates__11x17

Sat, August 4, 7:30 PM

Par 440 Restaurant & Lounge, SHORT HILLS

Solid Gold with Bobby Valli at Par 440

Arts & Entertainment Food & Drink

Man Stabbed in Valley Section of West Orange

July 18, 2018

WEST ORANGE – A West Orange man was stabbed Sunday evening during an attack in The Valley section of the township, according to officials.

Police were called the 300 block of Valley Road around 5:45 p.m. on a report of an aggravated assault. The 28-year-old victim was stabbed during an attack by a group of individuals who later fled the scene, according to township spokeswoman Susan ...

Livingston Town-Wide Campout, Movie Under the Stars Postponed

July 20, 2018

LIVINGSTON, NJ — ​Due to rain in the forecast, Livingston's Town-Wide Campout and Movie Under the Stars has been rescheduled from July 21 to Saturday, Aug. 18.

Tent setup will begin at 4:30 p.m., followed by games, a campfire, and Disney-Pixar's Coco at dusk!

More information about this annual event, part of Livingston's Youth Appreciation Celebration, can be ...

Rutgers Hikes Tuition, Student Fees for 2018-2019 Academic Year

July 20, 2018

NEW BRUNSWICK, NJ - Rutgers University Board of Governors this week approved a 2.3 percent hike in tuition and fees, as well as increases for dorm rooms and meals, for the 2018-2019 academic year.

The increase now brings the annual cost for undergraduate students to $14,975, which is $337 more than this past school year.

Student housing will increase 1.9 percent, ...

Bitcoin Scam Targets Livingston Residents

July 22, 2018

Dear Editor:

As I frequently write, scammers are becoming more sophisticated each day.

A resident called to advise me of the latest scam, somewhat obvious from the contents of the letter received, but with the many scandals being reported on in various media, a possible reality, depending upon the recipient, but certainly not this resident.

The letter only provided a possible email ...

Would Shedding

How much wood wouldn’t a woodchuck chuck if a woodchuck could chuck woodn’t?

 

Enough already.  

 

I get it.  It is an easy mistake to make, misusing would and wouldn’t.  It happens to me all the time.

 

“Honey, when I said I didn’t see any reason why I would go to the ballet, I meant to say I couldn’t see ...

Summer Storm Checklist

New Jersey gets its share of severe weather – and those closest to the coast are particularly vulnerable to hurricanes and high winds. Here are some things you can do to help improve the safety of your family and home before a storm hits:

·       Be informed. Find out where the nearest shelter is, and map out different routes you can take ...