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Atlantic Health System Cancer Care First in World to Begin Clinical Trial of Novel Virus-Based Immunotherapy for Late-Stage Melanoma; First Patient Enrolled

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Dr. Eric Whitman Leads Study of Experimental Drug That Uses Cold Virus to Disable Cancer Cells in Patients Who Have Not Responded to Other Treatments

Morristown, NJ Atlantic Health System Cancer Care is the first oncology institution in the world to sign on to, and to enroll the first patient in, a multicenter Phase IIa clinical trial of OBP-301 (Telomelysin®), a virus-based immunotherapy for late-stage melanoma that has not responded to other treatments. 

This leading-edge experimental therapy, which is under development by Japanese biotechnology company Oncolys BioPharma, uses the common cold virus to modify a gene that can selectively replicate in, and destroy, cancer cells. The study protocol was approved by the U.S. Food and Drug Administration (FDA) in June.

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The clinical trial is being led locally by Eric D. Whitman, MD, FACS, medical director of Atlantic Health System Cancer Care and director of the Carol G. Simon Cancer Center’s Atlantic Melanoma Center at Morristown Medical Center and Overlook Medical Center.

“This targeted immunotherapy holds great promise for improving survival rates in patients with unresectable and metastatic melanoma,” said Dr. Whitman.  “We are proud to have been chosen as the first site for this leading edge clinical trial, and happy to be able to offer a wide range of the latest established and experimental treatments to our patients.”

Melanoma, the most serious form of skin cancer, affects more than 50,000 people each year. Although the chances of having melanoma increase with age, the number of cases among young adults is rising every year. Melanoma can have serious health consequences and may even be fatal.

The OBP-301 trial is a multicenter, Phase IIa study to evaluate how melanoma tumors respond to injection of this drug in patients with Stage III and Stage IV melanoma -- that is, to determine how much the drug shrinks or destroys tumors after it is injected into them.  The study, which will also look at potential side effects, is “open label,” meaning that all participants in the study will receive OBP-301. 

OBP-301 is a type of virus known as an adenovirus. Adenoviruses are common in nature and when they multiply in normal human cells they may cause infections that result in symptoms like those of the common cold or the flu.  OBP-301 has been genetically changed from the original virus to reproduce in target cancer cells that are emitting a certain signal. As a result of this reproduction, OBP-301 is believed to burst and kill tumor cells.

Study participants will receive multiple injections into their tumors over a period of several weeks.  Blood tests will be done to evaluate the level of virus in patients’ systems, and for immune response monitoring. Dr. Whitman and colleagues will also evaluate how long it takes to get a response and how long responses last, as well as overall survival and progression-free survival rates.

In preclinical studies, Oncolys demonstrated OBP-301’s anti-tumor activity in various types of cancer cells.  A Phase I clinical trial in the U.S. demonstrated the drug’s safety, and showed that it shrank tumors in a majority of study participants, who had a variety of solid tumors.  Additional studies of the drug have been completed, or are underway, in Japan, Korea and Taiwan.

The Atlantic Melanoma Center, a clinical and research center of excellence, is an internationally-recognized program. The center’s multidisciplinary approach-- combining the expertise of board-certified surgeons, medical oncologists, pathologists, radiation oncologists and nurses – treats all forms of melanoma, including those in the skin, mucous membranes and eyes.  Patients receive the latest medical treatments, and when needed, melanoma surgery is also available. 

For more information on the OBP-301 clinical trial or other studies, please call the Atlantic Melanoma Center at 973-971-7111.  

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Sat, June 23, 10:00 AM

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Sat, June 23, 1:00 PM

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Summer Reading Kickoff - Teens

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Mon, June 25, 7:00 PM

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Government

Summer Concert Series Announced by Montville Twp Recreation

June 16, 2018

MONTVILLE, NJ – The Montville Township Recreation Department announced its summer concerts in the park lineup. The free concerts will be held on Tuesdays beginning on July 10, at the amphitheater beyond the Montville Township Public Library. Parking is available at the library (90 Horseneck Road) or in the high school parking lot (100 Horseneck Road). Assistance is available, for those who ...

Four Montville Residents Participate in American Legion Jersey Boys State Leadership Program

June 21, 2018

MONTVILLE, NJ - Four young men from Montville Township are among 883 other rising-seniors from New Jersey attending the 73rd session of the annual American Legion Jersey Boys State (ALJBS.)

At the event, taking place at Rider University this week, the students get to "govern and interact with their peers from across New Jersey as they run their own mythical 51st ...

May the Fourth Results in Donations to Lung Cancer Foundation from Cedar Hill Character Education Group

June 16, 2018

MONTVILLE, NJ – The Cedar Hill Fifth Grade Character Education Council sponsored May The 4th Be With You on Friday May 4 from in the Cedar Hill multi-purpose room. The event was to benefit the Lung Cancer Foundation of America. To raise money, each participant paid $5 for a Star Wars-themed scorecard. Upon completion of all events, scorecards were put in a raffle for a Star Wars video ...

Hot Rod Show in Roxbury Raises Money for Boy With Brain Disease

June 21, 2018

ROXBURY, NJ - They came from all over North Jersey to show off their chromed-out, big V8s. By day's end, they'd raised big bucks for a sick boy.

The annual North Jersey Street Rod Association (NJSRA) Father's Day Rod Run took place under sunny skies at Horseshoe Lake Park in Roxbury on Sunday. The charity event drew about 1,300 spectators and raised "a little ...

Former Jefferson School Staffer Facing Criminal Charges For Alleged Lewd Photos of Students

June 22, 2018

MAPLEWOOD, NJ - A former Jefferson Elementary School paraprofessional has been charged with criminal behavior believed to be related to lewd photos of students at the school that were found on his cell phone after he was arrested in Morris County on an unrelated sexual charge.

It also appears that South Orange Maplewood School District officials knew about the arrests as early as ...

Morris County Chamber Issues Statement About State Budget Negotiations and Proposed Tax Increases

June 21, 2018

MORRIS COUNTY, NJ - Paul Boudreau, president of the Morris County Chamber of Commerce, yesterday issued the following statement on the budget negotiations in Trenton:

“Individuals and businesses are shouldering a significant tax burden already in our state. Raising taxes sends a signal to our employers and future investors that New Jersey will remain uncompetitive for decades ...

Columns

OPEN HOUSES This Weekend 6/23 - 6/24, 2018

The following homes have OPEN HOUSES presented by RE/MAX Neighborhood Properties this weekend.

SATURDAY, June 23, 2018

  From 11 a.m. - 1 p.m.

  102 Magnolia Road, Unit 3, Ramsey

  Click HERE to see full listing.

 

  From 12 - 3 p.m.

  150 Barrister Drive, Butler

   Click HERE to see full listing.

 

 

SUNDAY, ...

OPEN HOUSES This Weekend 6/16 - 6/17, 2018

The following homes have OPEN HOUSES presented by RE/MAX NEIGHBORHOOD PROPERTIES this weekend.

SATURDAY, JUNE 16, 2018:

  From 12 - 2 p.m.

  201 English Place, Bernards Township

  Click HERE to see full listing.

 

 

SUNDAY, JUNE 17, 2018:

  From 1 - 3 p.m.

  170 Morris Avenue, Mountain Lakes

  Click HERE to see full ...

Open Houses this Weekend by Century 21

MONTVILLE, NJ - Following are the Century 21 Open Houses for this weekend:

Saturday, June 23 from 1 - 4 p.m.

Brownstones at Fairfield, Stonybrook Circle (Using GPS - Enter 66 Two Bridges Road)
3 Louis Drive, Montville

Sunday, June 24 from 12 - 3 p.m.

6 Woodside Drive, Montville Township

Sunday, June 24 from 1 - 4 p.m.

Brownstones at ...

AtlantiCast

AtlantiCast Episode 17

On this week’s AtlantiCast, it’s National Men’s Health Month, so check out important health tips for you or the men in your life, learn about groundbreaking research into breast cancer treatment that could mean an end to chemotherapy for some patients, meet a local sports hero who’s living his baseball dreams thanks to Goryeb Children’s Hospital and much ...

'Half Time' delivers with sterling cast

MILLBURN, NJ – The Paper Mill Playhouse is putting on a smashing new production of “Half Time” to round out its current season.

With actress Georgia Engel in an engaging performance, the cast also features Donna McKehnie, Andre De Shieilds and Lilias White, among a host of other talents.

The musical centers on an effort to have seniors perform a dance number during ...

'Half Time' lights up Paper Mill stage

‘Half Time’ turns the tables on aging in gleeful production

By Liz Keill

MILLBURN, NJ – The Paper Mill Playhouse is putting on a smashing new production of “Half Time” to round out its current season.

With actress Georgia Engel in an engaging performance, the cast also features Donna McKehnie, Andre De Shieilds and Lilias White, among a host of other ...

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