Health & Wellness

Press Releases

Atlantic Health System Cancer Care First in World to Begin Clinical Trial of Novel Virus-Based Immunotherapy for Late-Stage Melanoma; First Patient Enrolled

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Dr. Eric Whitman Leads Study of Experimental Drug That Uses Cold Virus to Disable Cancer Cells in Patients Who Have Not Responded to Other Treatments

Morristown, NJ Atlantic Health System Cancer Care is the first oncology institution in the world to sign on to, and to enroll the first patient in, a multicenter Phase IIa clinical trial of OBP-301 (Telomelysin®), a virus-based immunotherapy for late-stage melanoma that has not responded to other treatments. 

This leading-edge experimental therapy, which is under development by Japanese biotechnology company Oncolys BioPharma, uses the common cold virus to modify a gene that can selectively replicate in, and destroy, cancer cells. The study protocol was approved by the U.S. Food and Drug Administration (FDA) in June.

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The clinical trial is being led locally by Eric D. Whitman, MD, FACS, medical director of Atlantic Health System Cancer Care and director of the Carol G. Simon Cancer Center’s Atlantic Melanoma Center at Morristown Medical Center and Overlook Medical Center.

“This targeted immunotherapy holds great promise for improving survival rates in patients with unresectable and metastatic melanoma,” said Dr. Whitman.  “We are proud to have been chosen as the first site for this leading edge clinical trial, and happy to be able to offer a wide range of the latest established and experimental treatments to our patients.”

Melanoma, the most serious form of skin cancer, affects more than 50,000 people each year. Although the chances of having melanoma increase with age, the number of cases among young adults is rising every year. Melanoma can have serious health consequences and may even be fatal.

The OBP-301 trial is a multicenter, Phase IIa study to evaluate how melanoma tumors respond to injection of this drug in patients with Stage III and Stage IV melanoma -- that is, to determine how much the drug shrinks or destroys tumors after it is injected into them.  The study, which will also look at potential side effects, is “open label,” meaning that all participants in the study will receive OBP-301. 

OBP-301 is a type of virus known as an adenovirus. Adenoviruses are common in nature and when they multiply in normal human cells they may cause infections that result in symptoms like those of the common cold or the flu.  OBP-301 has been genetically changed from the original virus to reproduce in target cancer cells that are emitting a certain signal. As a result of this reproduction, OBP-301 is believed to burst and kill tumor cells.

Study participants will receive multiple injections into their tumors over a period of several weeks.  Blood tests will be done to evaluate the level of virus in patients’ systems, and for immune response monitoring. Dr. Whitman and colleagues will also evaluate how long it takes to get a response and how long responses last, as well as overall survival and progression-free survival rates.

In preclinical studies, Oncolys demonstrated OBP-301’s anti-tumor activity in various types of cancer cells.  A Phase I clinical trial in the U.S. demonstrated the drug’s safety, and showed that it shrank tumors in a majority of study participants, who had a variety of solid tumors.  Additional studies of the drug have been completed, or are underway, in Japan, Korea and Taiwan.

The Atlantic Melanoma Center, a clinical and research center of excellence, is an internationally-recognized program. The center’s multidisciplinary approach-- combining the expertise of board-certified surgeons, medical oncologists, pathologists, radiation oncologists and nurses – treats all forms of melanoma, including those in the skin, mucous membranes and eyes.  Patients receive the latest medical treatments, and when needed, melanoma surgery is also available. 

For more information on the OBP-301 clinical trial or other studies, please call the Atlantic Melanoma Center at 973-971-7111.  

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Roxbury

Upcoming Events

Tue, February 27, 11:00 AM

Roxbury Public Library, Succasunna

Roxbury Area Preschool Fair

Education

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Thu, March 1, 6:30 PM

Roxbury Public Library, Succasunna

Celtic Harp Concert

Arts & Entertainment

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Sat, March 3, 8:00 AM

Redeemer Lutheran Church, Succasunna

Boy Scout Troop 159 Pancake Breakfast

Food & Drink

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Sat, March 10, 7:30 PM

Investors Bank Theater, Succasunna

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Arts & Entertainment

Columns

AtlantiCast

AtlantiCast: Episode 12

On this week’s episode of AtlantiCast, decade of excellence makes headlines, as Atlantic Health’s place on Fortune Magazine’s 100 Best Companies to Work For List leads off the newest episode of AtlantiCast. Also on this week’s show, check out the newest “hybrid” operating room at Morristown Medical Center and find out how Atlantic Health is helping local ...

Sponsors of Roxbury's Best Journalism

Getting it Right From the Start; Roxbury Realtor Bob Idakaar

ROXBURY, NJ – Twenty years ago this month, Bob Idakaar experienced an unprofessional real estate agent. That’s when he decided to be a good one.

Idakaar, a lifelong Succasunna resident and TAPinto Roxbury sponsor, bought his fifth home in July 1997. A big event, one that could have been joyous, ended up being stressful and unenjoyable.

“I had a bad experience,” he ...

Roxbury Diner: Homespun Hospitality Through Thick and Thin

ROXBURY, NJ – Roxbury was being buried in snow March 14 and most businesses were closed. Not Roxbury Diner.

Roxbury Diner isn’t like most businesses.For co-owner Jimmy Dontas, a snowstorm – even a blizzard – isn’t a reason to suspend operations. Instead, it’s a call to action.

To many in town, Roxbury Diner – a TAPinto Roxbury sponsor – is ...

It Began With Filling Your Tank; Now They Fix Your Grandson’s Car

When we drive east on Route 10 through Roxbury, many of us might remember a Shell station at the Randolph border next to the golf range. It was in that station that Nancy and Peyton Knight began their long history of auto repair in the township.

That was 1983 and soon the Knights’ business grew and expanded. The humble gas station gradually morphed into a state-of-the-art ...

Orthopedic Urgent Care in Roxbury - Open Late and on Weekends

ROXBURY, NJ – It’s a pleasant Sunday morning, you’re playing volleyball in the back yard with the kids and – forgetting you’re not 17 anymore – you jump up to smack that ball.

Instead of feeling the satisfaction of an unanswered spike, you feel the stinging pain of a wounded ankle.

The only good thing about this scenario is that you live in Roxbury. That ...

Love of His Hometown Drives Roxbury Realtor Ted Miller II

ROXBURY, N.J. – Most local real estate agents can tell you what houses are for sale in Roxbury. Ted Miller can probably tell you what was there before the houses were built. 

Miller, a TAPinto Roxbury sponsor, grew up in the township and has watched it change from bucolic to bustling. The son of a local Realtor, ...

Three Sons at His Side, John Klein Makes Plumbing a Family Affair

ROXBURY, N.J. - Running water and a warm house during winter months are some of the most important amenities we enjoy -- and often take for granted -- in our homes.

With John Klein Plumbing & Heating, a TAPinto Roxbury sponsor, residents of Roxbury (and beyond) have a father-and-sons company they count on for reliable plumbing and heating services to keep the ...

Letters to TAPinto Roxbury

Roxbury Library Blood Drive Will Help 111 People

January 31, 2018

Dear Editor,

On Jan. 17, the Roxbury Public Library held its first American Red Cross blood drive. Despite snow and less than ideal driving conditions, dozens of area residents showed up to donate blood, nearly doubling the Red Cross' quota for the day! 

The drive was held in honor of local resident, Matt Adonis. Having a blood rive in his honor was a lovely way to bring awareness ...

Two From Roxbury Area Make Loyola Dean's List

February 22, 2018

BALTIMORE, MD -- Two students from the Roxbury area made the Loyola University fall 2017 Dean's List.

In order to qualify for the Dean's List at Loyola, a student must achieve a minimum QPA of at least 3.500 for the term, provided that, in the term they have successfully completed courses totaling a minimum of 15 credits.

The following local students have achieved this ...

Three from Roxbury Area Make James Madison Dean's List

HARRISONBURG, VA -- James Madison University is pleased to announce the following students made the dean's list for the fall 2017 semester:

Jordan Israel Taylor of Flanders .

Nicolette Thorkildsen of Flanders .

Olivia J Viparina of Ledgewood .

Students who earn dean's list honors must carry at least 12 graded credit hours and earn a GPA of between 3.5 and 3.899.

Totaro Makes Hofstra Dean's List

HEMPSTEAD, NY -- Julia Totaro of Mt. Arlington excelled during the Fall 2017 semester, achieving a GPA of at least 3.5 to earn a spot on the Hofstra University Dean's List.

Roxbury Area Students Named to the Marist College Dean's List

POUGHKEEPSIE, NY -- The following local students have been named to the Marist College Dean's List for the Fall 2017 semester:

Mariah Christian of Flanders is a member of the Class of 2018 and is majoring in Communication.

Jenna Ficula of Flanders is a member of the Class of 2019 and is majoring in Computer Science.

Erika Hofgesang of Kenvil, is a member of the Class of ...

Roxbury Area Students Make Clemson Lists

CLEMSON, SC - Kristin Elizabeth Agosta of Flanders has been named to the President's List at Clemson University for the fall 2017 semester and three other area students were named to the Dean's List.

Agosta is majoring in Accounting.

To be named to the President's List, a student must achieve a 4.0 (all As) grade-point average.

The three Roxbury ...

Roxbury Area Students Make Seton Hall Dean's List

SOUTH ORANGE, NJ -- Nineteen Seton Hall University students from the Roxbury area qualified for the Fall 2017 dean's list, according to the university. The students are:

Siddharth Bector of Flanders 

Nicholas Czipo of Wharton 

Gabriella DePiano of Ledgewood

Darrelle Dilangalen of Succasunna

Katherine Dolan of Flanders 

Kimberly Gong of Kenvil

Edward Guenzel ...

Press Releases

Assistance Programs Available for JCP&L Customers to Help with Winter Heating Bills

February 13, 2018

MORRISTOWN,NJ - As the cold weather continues, financial assistance programs are available for Jersey Central Power & Light (JCP&L) customers who need help with winter heating bills.

Assistance to qualifying JCP&L customers is available through the Lifeline, Universal Service Fund (USF), Weatherization, Payment Assistance for Gas and Electric (PAGE) and New Jersey SHARES ...

TAPinto.net Named Partner of the Year by NJ News Commons

NEW PROVIDENCE, NJ -  TAPinto.net has been named Partner of the Year by NJ News Commons, a network of more than 230 news organizations across New Jersey.  The award goes to a journalist or news organization that showed overall excellence in their work for 2017.    

Joe Amditis, Associate Director of the Center for Cooperative Media, said TAPinto won the award ...