Health & Wellness

Press Releases

Atlantic Health System Cancer Care First in World to Begin Clinical Trial of Novel Virus-Based Immunotherapy for Late-Stage Melanoma; First Patient Enrolled

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Dr. Eric Whitman Leads Study of Experimental Drug That Uses Cold Virus to Disable Cancer Cells in Patients Who Have Not Responded to Other Treatments

Morristown, NJ Atlantic Health System Cancer Care is the first oncology institution in the world to sign on to, and to enroll the first patient in, a multicenter Phase IIa clinical trial of OBP-301 (Telomelysin®), a virus-based immunotherapy for late-stage melanoma that has not responded to other treatments. 

This leading-edge experimental therapy, which is under development by Japanese biotechnology company Oncolys BioPharma, uses the common cold virus to modify a gene that can selectively replicate in, and destroy, cancer cells. The study protocol was approved by the U.S. Food and Drug Administration (FDA) in June.

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The clinical trial is being led locally by Eric D. Whitman, MD, FACS, medical director of Atlantic Health System Cancer Care and director of the Carol G. Simon Cancer Center’s Atlantic Melanoma Center at Morristown Medical Center and Overlook Medical Center.

“This targeted immunotherapy holds great promise for improving survival rates in patients with unresectable and metastatic melanoma,” said Dr. Whitman.  “We are proud to have been chosen as the first site for this leading edge clinical trial, and happy to be able to offer a wide range of the latest established and experimental treatments to our patients.”

Melanoma, the most serious form of skin cancer, affects more than 50,000 people each year. Although the chances of having melanoma increase with age, the number of cases among young adults is rising every year. Melanoma can have serious health consequences and may even be fatal.

The OBP-301 trial is a multicenter, Phase IIa study to evaluate how melanoma tumors respond to injection of this drug in patients with Stage III and Stage IV melanoma -- that is, to determine how much the drug shrinks or destroys tumors after it is injected into them.  The study, which will also look at potential side effects, is “open label,” meaning that all participants in the study will receive OBP-301. 

OBP-301 is a type of virus known as an adenovirus. Adenoviruses are common in nature and when they multiply in normal human cells they may cause infections that result in symptoms like those of the common cold or the flu.  OBP-301 has been genetically changed from the original virus to reproduce in target cancer cells that are emitting a certain signal. As a result of this reproduction, OBP-301 is believed to burst and kill tumor cells.

Study participants will receive multiple injections into their tumors over a period of several weeks.  Blood tests will be done to evaluate the level of virus in patients’ systems, and for immune response monitoring. Dr. Whitman and colleagues will also evaluate how long it takes to get a response and how long responses last, as well as overall survival and progression-free survival rates.

In preclinical studies, Oncolys demonstrated OBP-301’s anti-tumor activity in various types of cancer cells.  A Phase I clinical trial in the U.S. demonstrated the drug’s safety, and showed that it shrank tumors in a majority of study participants, who had a variety of solid tumors.  Additional studies of the drug have been completed, or are underway, in Japan, Korea and Taiwan.

The Atlantic Melanoma Center, a clinical and research center of excellence, is an internationally-recognized program. The center’s multidisciplinary approach-- combining the expertise of board-certified surgeons, medical oncologists, pathologists, radiation oncologists and nurses – treats all forms of melanoma, including those in the skin, mucous membranes and eyes.  Patients receive the latest medical treatments, and when needed, melanoma surgery is also available. 

For more information on the OBP-301 clinical trial or other studies, please call the Atlantic Melanoma Center at 973-971-7111.  

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Thu, July 19, 6:00 PM

La Strada Ristorante, Randolph

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Sun, July 22, 9:00 AM

Henry Bona Pools & Spas, Kenvil

Bona Pools Customer Appreciation Sale!

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Have You Seen Buttons?

July 11, 2018

MOUNT OLIVE, NJ - Residents of Roxbury living near Flanders are asked to keep an eye out for a lost female Yorkie mix that has been missing since July 7.

"Buttons" was last seen near Kevin Drive and Christopher Court in Flanders. The dog, described as friendly but shy, is brown with dark highlights and a white chest patch. If you see her, please call 973-219-9323.

Columns

Peyton Knight's Pointers for Safer Driving

Many customers ask my advice for ways to add more years of life to their vehicles. Here are a few pointers from my 35 years of experience in the auto repair industry, as well as some tips to keep you safer on the road.  

1.    Pull Through a Parking Spot.  Pull through to the other side of a parking space so your vehicle faces forward out ...

More Snow! Let Your Kid Drive in It!

ROXBURY, NJ - We are again about to be walloped by a snowstorm. These words, first written at the beginning of winter, need to be reiterated:

Many parents with a new driver at home will see the storm approaching and instinctively decide to not allow their kids to get behind the wheel until the snow's been cleared.

They might want to rethink that.

When it snows, ...

Is Your Car Ready for Old Man Winter?

You know it’s coming: That first frigid morning when you discover your car is covered in ice. Old Man Winter has reared his ugly head once again to wreak havoc on your car and your ride to work. 

Well, I’ve got one thing to say about that: Let’s be ready for him this year!

Owning a repair shop for over 30 years, I have spent many harsh winters coaxing a dead ...

AtlantiCast

AtlantiCast: Episode 18

On this week’s AtlantiCast, you’ll find out how accessing care at Atlantic Health System is now easier, more affordable and closer to home than ever, learn which item from the produce aisle could be the newest weapon against cancer, see what Atlantic Health System, the New York Times and Instagram all have in common and much more.

 

 

AtlantiCast Episode 17

On this week’s AtlantiCast, it’s National Men’s Health Month, so check out important health tips for you or the men in your life, learn about groundbreaking research into breast cancer treatment that could mean an end to chemotherapy for some patients, meet a local sports hero who’s living his baseball dreams thanks to Goryeb Children’s Hospital and much ...

Letters to TAPinto Roxbury

A Problem and a Solution

July 17, 2018

Greetings, residents of Roxbury Township.  Let me begin by thanking you for the opportunity to serve as the high school principal for the past 15 years.  It has been an honor and a pleasure to do so.

As I “walk into the sunset,” I’d like to bring an important issue to your attention.  It is a significant issue that will plague the district for years to come if ...

Warsaw of Ledgewood Makes St. Lawrence Dean's List

July 2, 2018

CANTON, NY - Nolan Warsaw of Ledgewood has been selected for inclusion on St. Lawrence University's Dean's List for academic achievement during the Spring 2018 semester.

Warsaw is a member of the Class of 2021. Warsaw attended Roxbury High School.

To be eligible for the Dean's List, a student must have completed at least four courses and have an academic average of 3.6 based on ...

Two From Roxbury Graduate From Roger Williams

BRISTOL, RI - The following local residents were among the 1,127 students who received their degrees in May as part of the Class of 2018

Paul Bohrer of Succasunna N, with a B.A. in Public Health

Samuel Sherwood of Succasunna NJ (07876), with a B.S. in Finance

Fleming Chosen to Represent RHS at Annual NJ HOBY Seminar

ROXBURY, NJ - Roxbury High School sophomore Allison Fleming from Succasunna represented Roxbury High School at this year’s annual NJ Hugh O’Brian Youth (HOBY) Leadership Seminar.

Fleming spent three days in June at Kean University with more than 300 other sophomores from around the state.

Founded in 1958, HOBY’s mission is to inspire and develop our global ...

Press Releases

Roxbury BOYS & GIRLS INVITED TO FREE SUMMER ADVENTURE NIGHTS

July 13, 2018

Events Will Include STEM, Shooting sports, games and More!

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STANHOPE, NJ – July 5, 2018– Time for the whole family to experience adventure this summer!  Have some free summer evenings and ready for a summer evening of family fun?!  Families are invited to attend any of four Family Adventure Nights at Camp Wheeler or Watchung Day Camp at no ...

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How often do you read TAPinto?  Have you downloaded the TAPinto APP?  These are a few of the questions for readers in our 2018 TAPinto Reader Survey.

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