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Atlantic Health System Cancer Care First in World to Begin Clinical Trial of Novel Virus-Based Immunotherapy for Late-Stage Melanoma; First Patient Enrolled

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Dr. Eric Whitman Leads Study of Experimental Drug That Uses Cold Virus to Disable Cancer Cells in Patients Who Have Not Responded to Other Treatments

Morristown, NJ Atlantic Health System Cancer Care is the first oncology institution in the world to sign on to, and to enroll the first patient in, a multicenter Phase IIa clinical trial of OBP-301 (Telomelysin®), a virus-based immunotherapy for late-stage melanoma that has not responded to other treatments. 

This leading-edge experimental therapy, which is under development by Japanese biotechnology company Oncolys BioPharma, uses the common cold virus to modify a gene that can selectively replicate in, and destroy, cancer cells. The study protocol was approved by the U.S. Food and Drug Administration (FDA) in June.

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The clinical trial is being led locally by Eric D. Whitman, MD, FACS, medical director of Atlantic Health System Cancer Care and director of the Carol G. Simon Cancer Center’s Atlantic Melanoma Center at Morristown Medical Center and Overlook Medical Center.

“This targeted immunotherapy holds great promise for improving survival rates in patients with unresectable and metastatic melanoma,” said Dr. Whitman.  “We are proud to have been chosen as the first site for this leading edge clinical trial, and happy to be able to offer a wide range of the latest established and experimental treatments to our patients.”

Melanoma, the most serious form of skin cancer, affects more than 50,000 people each year. Although the chances of having melanoma increase with age, the number of cases among young adults is rising every year. Melanoma can have serious health consequences and may even be fatal.

The OBP-301 trial is a multicenter, Phase IIa study to evaluate how melanoma tumors respond to injection of this drug in patients with Stage III and Stage IV melanoma -- that is, to determine how much the drug shrinks or destroys tumors after it is injected into them.  The study, which will also look at potential side effects, is “open label,” meaning that all participants in the study will receive OBP-301. 

OBP-301 is a type of virus known as an adenovirus. Adenoviruses are common in nature and when they multiply in normal human cells they may cause infections that result in symptoms like those of the common cold or the flu.  OBP-301 has been genetically changed from the original virus to reproduce in target cancer cells that are emitting a certain signal. As a result of this reproduction, OBP-301 is believed to burst and kill tumor cells.

Study participants will receive multiple injections into their tumors over a period of several weeks.  Blood tests will be done to evaluate the level of virus in patients’ systems, and for immune response monitoring. Dr. Whitman and colleagues will also evaluate how long it takes to get a response and how long responses last, as well as overall survival and progression-free survival rates.

In preclinical studies, Oncolys demonstrated OBP-301’s anti-tumor activity in various types of cancer cells.  A Phase I clinical trial in the U.S. demonstrated the drug’s safety, and showed that it shrank tumors in a majority of study participants, who had a variety of solid tumors.  Additional studies of the drug have been completed, or are underway, in Japan, Korea and Taiwan.

The Atlantic Melanoma Center, a clinical and research center of excellence, is an internationally-recognized program. The center’s multidisciplinary approach-- combining the expertise of board-certified surgeons, medical oncologists, pathologists, radiation oncologists and nurses – treats all forms of melanoma, including those in the skin, mucous membranes and eyes.  Patients receive the latest medical treatments, and when needed, melanoma surgery is also available. 

For more information on the OBP-301 clinical trial or other studies, please call the Atlantic Melanoma Center at 973-971-7111.  

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SOMA

Columbia High School Principal's Removal Raises More Questions Than It Answers

The last Twitter post from Columbia High School principal Elizabeth Aaron is very telling. 

The four-year CHS schools chief, who was recently, surprisingly, reassigned to a vague “Principal on Special Assignment” post by the school district, was a Twitter regular on her @CougarPrincipal account. There she would often promote the school’s successes and notable staff and ...

AtlantiCast

AtlantiCast: Episode 18

On this week’s AtlantiCast, you’ll find out how accessing care at Atlantic Health System is now easier, more affordable and closer to home than ever, learn which item from the produce aisle could be the newest weapon against cancer, see what Atlantic Health System, the New York Times and Instagram all have in common and much more.

 

 

Maplewood Police Blotter - Stolen Vehicle in Maplewood Recovered by South Orange Police

July 18, 2018

July 11 - Motor Vehicle Theft; Sometime during the early morning hours, a vehicle was stolen from a residence on the 400 block of Richmond Ave. The vehicle was recovered by the South Orange Police Department the same morning.

Maplewood Police Blotter - Two Robberies Reported on July 5

July 2 - Motor Vehicle Theft; Sometime over the previous two days, a U-Haul truck was stolen from a business on Newark Way.

July 4 - Theft from Auto; During the overnight hours an unsecured vehicle parked on Elberta Rd was entered and keys were stolen from it.

July 5 - Robberies; At approximately 1:30 a.m., a male was assaulted by two males ridding bicycles while he was walking on ...

Free 'Movies in the Park' on July 18 and August 23 in Maplewood

July 16, 2018

MAPLEWOOD, NJ - Free "Movies in the Park" are planned for Wednesday, July 18, and Thursday, August 23, a program hosted by the Maplewood Police Department in conjunction with the Maplewood Recreation Department, the Maplewood Office of Cultural Affairs, SOMA Film Festival and SOMA Municipal Alliance.

The movie on July 18 will be The Incredibles, shown in Dehart Park, ...

National Weather Service Issues Heat Advisory Through 6 p.m. Tuesday, July 17

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Upcoming Events

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Sat, July 21, 7:30 PM

Par 440 Restaurant & Lounge, SHORT HILLS

Solid Gold with Bobby Valli at Par 440

Arts & Entertainment Food & Drink

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Thu, July 26, 6:00 PM

River Barge Park & Marina, Carlstadt

Meadowlands Discovery Sunset Eco-Cruise

Green Travel

Fri, July 27, 6:30 PM

Calloway's Restaurant & Bar, Staffordville

Family Promise SOC Fundraiser at Calloway's

Food & Drink Giving Back

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Fri, July 27, 7:00 PM

Par 440 Restaurant & Lounge, Short Hills

The Extra Rich In Class Dinner Show with E.R.I.C.

Arts & Entertainment Food & Drink

Statement From Emergency Committee to Reinstate Principal Aaron

July 10, 2018

** TUESDAY RALLY IS CANCELLED **

We created a movement. We leveraged our collective 1,600 voices and forced the District leadership to sit with us today [Monday] and discuss the poorly communicated, weekend announcement that CHS Principal Elizabeth Aaron was being reassigned.

Our meeting was a first step in both accountability and transparency as Dr. Ficarra revealed Principal ...

Coalition on Race Responds to Changes in School District Administrators

The Board of Trustees of the Community Coalition on Race seeks racial equity, integration, and excellence in education for all students in our schools. While the pace of change has been frustratingly slow, we have seen some progress. Yet, candidly, there are too many students of color who are not well served in SOMA, who still experience segregated classrooms and who still suffer from racial ...

Those Boarded-Up Homes in the West Ward? Newark Has a Plan for Them.

July 19, 2018

NEWARK, NJ - The city is using the power of eminent domain to reduce the number of condemned homes and vacant lots scattered throughout the West Ward.

The redevelopment plan for the West Ward was introduced in 2016 and encompasses properties from the border of Irvington to South 13th Street between South Orange Avenue and 16th Avenue. One of the main goals of the plan is to support new ...

Lawmakers Denounce SCOTUS Nomination at Essex County Courthouse

NEWARK, NJ - State Assemblywoman Eliana Pintor Marin said it was important to support local women’s health organizations at a state level should President Donald Trump’s Supreme Court justice nominee be approved.

The assemblywoman joined state Sen. Teresa Ruiz, congressional leaders and women's rights groups yesterday at the steps of the Essex County Courthouse ...

Rutgers Hikes Tuition, Student Fees for 2018-2019 Academic Year

July 18, 2018

NEW BRUNSWICK, NJ - Rutgers University Board of Governors today approved a 2.3 percent hike in tuition and fees, as well as increases for dorm rooms and meals, for the 2018-2019 academic year.

The increase now brings the annual cost for undergraduate students to $14,975, which is $337 more than this past school year.

Student housing will increase 1.9 percent, and ...

NJ Residents Take Action Against White Supremacist Fliers Found Around Bridgewater, Bedminster, Other Local Areas

BRIDGEWATER, NJ - Residents of Bridgewater, Somerville, Morristown and surrounding communities are mobilizing for action after they found posters around town promoting Identity Evropa, which the Anti-Defamation League (ADL) has labeled a white supremacist group.

According to Bridgewater resident Stacey Friedlander, a member of the “Not In Our Town – Bridgewater/Raritan” ...

Woolley Home Solutions Building Has Unique Historical Stained Glass Window

July 21, 2018

Have you ever spotted this Stained Glass Window on our building? It's compliments of the first Methodist Church in town. The repairman saw our 1924 Autocar Truck parked outside and created this beautiful piece and installed it in our front window. The church was knocked down years ago and its location is now Walgreen's parking lot.

The church was originally built in 1836 when Maplewood ...

New Plumber Joins the Woolley Home Solutions Team

We are excited to announce a new addition to the Woolley team! Our new plumber, Oscar Buonafina, is an expert plumber with nearly a decade of industry experience serving New Jersey homeowners. He is also a NJ Master Plumber Since 2007. As a military veteran, Oscar truly understands hard work and commitment, and we’re so happy to bring him on board!

"I believe in service to people ...

Maplewood Brings Local Youth to the Governing Table With the Youth Advisory Committee

The Maplewood Township Committee cordially invites diverse student residents of Maplewood who are enrolled in private or public school in grades 8 through 12 to apply to serve on its new Youth Advisory Committee.  In order to continue empowering local youth whose recent advocacy on - gun safety, safe schools, voting rights, immigration, greater institutional equity and inclusion, to name a ...