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Brain Cancer Study Opens at Overlook Medical Center - One of Four Sites in Country

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Kurt Jaeckle, MD, co-director of the Gerald J. Glasser Brain Tumor Center at Overlook Medical Center, and medical director of the Atlantic Center for Research, is leading a phase III study of novel drug VAL-083, which has already shown promise in Glioblastoma and other cancers.  The study is for patients whose glioblastoma multiforme or gliosarcoma has progressed during or after treatment with the standard of care chemo-radiation therapy. Other study locations are: Kaiser Permanente Los Angeles Medical Center; University of California, San Francisco; and Dent Neurosciences Research Center, Amherst, NY.

“Glioblastoma is very difficult to treat, and I am encouraged by previously reported results with VAL-083,” said Dr. Jaeckle.  “I am also happy that some of the most innovative pharmaceutical companies are looking to Atlantic Health System when they seek to test new types of treatments for brain tumors. The availability of this and other neuro-oncology clinical trials provides a benefit to our patients, and gives me hope for the future.”

Glioblastoma is the most common and most aggressive type of brain cancer, with typical survival of 14-20 months for newly diagnosed patients.  Standard treatment includes surgery to remove as much of the tumor as is safely possible, followed by radiation therapy and chemotherapy with temozolomide.  Nearly all glioblastoma patients will relapse.  Gliosarcoma, which is also being studied in this clinical trial, is a rare and equally aggressive form of glioblastoma. 

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VAL-083 is a first-in-class small molecule chemotherapy drug.  This means that the molecular structure of VAL-083 is not similar in chemical structure (an analogue) or derivative of other small molecule chemotherapeutics approved for the treatment of cancer.  VAL-083 is unique in that it has been shown to overcome cancer cells’ resistance to MGMT, a DNA-repair mechanism that causes recurrent glioblastoma to resist treatment with temozolomide.  Many glioblastoma tumors express large amounts of MGMT, making them difficult to treat with currently available chemotherapies.

According to DelMar Pharmaceuticals, VAL-083 has been assessed in 42 Phase I and Phase II clinical trials sponsored by the National Cancer Institute as a treatment against various cancers. Published pre-clinical and clinical data suggest that VAL-083 may be active against a range of tumor types, including lung, brain, cervical, ovarian tumors and hematologic (blood) cancers.  Earlier clinical trials have shown that VAL-083 is comparable or superior to other chemotherapies in treating glioblastoma.

To learn more about study inclusion and exclusion criteria, go to the Atlantic Center for Research: research.atlantichealth.org/VAL_083.

About the Gerald J. Glasser Brain Tumor Center

Specialists at the Gerald J. Glasser Brain Tumor Center treat a variety of brain tumors and related conditions, including acoustic neuromas and schwannomas; anaplastic astrocytomas, oligodendrogliomas and low-grade gliomas; brain, epidural and leptomeningeal metastases; ependymomas; glioblastomas; low-grade astrocytomas; lymphomas; meningiomas; medulloblastomas; peripheral nerve, pineal and pituitary tumors; rare glial and neuronal tumors; sarcomas; and spinal cord tumors. The center features a multidisciplinary panel of experts who specialize in neurosurgery, skull base surgery, neuroradiology, radiation oncology, neuro-oncology, medical oncology, neurology, neuropathology and social work. Overlook Medical Center also has the largest CyberKnife® program in the tri-state area for the treatment of brain tumors. The brain tumor center recently moved into its own space on the main level of Overlook Medical Center, in order to foster an optimal, convenient patient-centered experience.

Dr. Jaeckle sees patients at the Gerald J. Glasser Brain Tumor Center of Overlook Medical Center’s Atlantic Neuroscience Institute and Carol G. Simon Cancer Center, 99 Beauvoir Avenue, Summit, NJ. He and other members of the Gerald J. Glasser Brain Tumor Center can be reached at (908) 516-2941. For more information on this clinical trial or other studies, please call the Atlantic Center for Research at (973) 971-5235.

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AtlantiCast

AtlantiCast: Episode 15

On this week’s AtlantiCast, learn some important tips for controlling and avoiding diabetes from an Atlantic Health System expert, see how Atlantic Health is advancing cutting-edge research, hear what’s being done to keep health care environmentally friendly and much more!

 

Maplewood Police Blotter - Two Motor Vehicle Thefts Reported, One Recovered

May 16, 2018

May 7 - Burglary; Sometime during the prior two days, entry was forced to a business on Newark Way.  The keys to a GMC van were then taken from inside the business and the van was stolen.

 

May 7 - Motor Vehicle Theft; At approximately 9:30 p.m., a Jeep left unattended and running in the parking lot of 7-11 on Irvington Ave was stolen. The vehicle was later recovered in ...

South Orange Police Blotter - More Than 10 Vehicle Burglaries Reported

South Orange Police Blotter as of May 14

Auto Theft - A Roland Ave resident reported that sometime between 10:30 pm, Thursday 5-10-18 & 7:30 am, Friday 5-11-18 actor(s) unknown stole his vehicle (2016 Mitsubishi), which was parked in his driveway of his residence at the time.

Burglary to Auto - A Vose Ave resident reported that sometime between 10:45 pm, Wednesday 5-2-18 & 8:00 ...

South Orange-Maplewood Adult School Honors Melissa Kopecky and Sarah Lester at Annual Meeting

May 23, 2018

SOUTH ORANGE AND MAPLEWOOD, NJ - The South Orange-Maplewood Adult School (SOMAS) honored Melissa Kopecky, Director of the South Orange Library, and Sarah Lester, Director of the Maplewood Memorial Library, at its Annual meeting on May 21, according to a press release from SOMAS.

Kopecky has been the director of the South Orange Public Library for the last 14 years, and Lester ...

Food, Fun, Music and Murals at MayFest in Maplewood on Sunday {Photos}

MAPLEWOOD, NJ - Crowds came out to enjoy MayFest on Springfield Avenue on Sunday, with plenty of food, live music and performances, and a chance to see the new murals and meet the artists who created them, as well as local residents Michael and Viktorija painting their mural “I Am Maplewood." 

Thank you to Carl Patterson of CP Photo Op Photography for use of ...

Upcoming Events

Wed, May 23, 12:00 PM

Temple Sharey Tefilo-Israel, South Orange

The Purposes and Rhythms of Jewish Living

Education Religions And Spirituality

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Fri, May 25, 7:00 PM

Par 440 Restaurant & Lounge, Short Hills

The Extra Rich In Class Dinner Show with E.R.I.C.

Arts & Entertainment Food & Drink

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Fri, May 25, 7:00 PM

Par 440 Restaurant & Lounge, Short Hills

The Extra Rich In Class Dinner Show with E.R.I.C.

Arts & Entertainment Food & Drink

Sun, May 27, 11:00 AM

The Ethical Culture Society of Essex County, Maplewood

Memorial Day Colloquy: What We Honor and How We ...

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SURVIVING A STROKE: Quick Medical Response Gives Mom Her Life Back

Carotid artery dissection. It’s one of the most common causes of stroke in younger adults.

And while you might not associate the word “stroke” with younger patients, the condition – if not treated immediately – could lead to paralysis and even death.

Lindsey Singh can attest to the importance of immediacy. The 31-year-old mother of two from Flanders experienced ...

Parsippany Septuagenarian Becomes NJIT's Oldest Engineering Grad

May 23, 2018

NEWARK, NJ - It was about five minutes after Robert Dresnack’s Water Resources Engineering class had begun when a septuagenarian poked his head into the room at NJIT. Puzzled, the professor inquired, “May I help you?”

In fact, he could. “I’m a student in this class,” replied Chris Antholis, then 72, who was six years into his quest to earn a Bachelor of ...

Uniacke Named Bridges Outreach Executive Director as Bhatt, Tulloch Announce Retirement

SUMMIT, NJ - Bridges Outreach, Inc. Executive Director Lois Bhatt and Deputy Executive Director Bethany Tulloch have announced their retirement and, effective May 29, Richard J. Uniacke will begin his tenure as the Summit-based nonprofit's new Executive Director.

Uniacke, who will become just the organization's third executive director in three decades, was ...

Phase II of the Stuyvesant Avenue Streetscape Project Set to Begin in Union

May 22, 2018

UNION, NJ – A groundbreaking ceremony took place Monday morning for Phase II of the Stuyvesant Avenue Streetscape Project which is set to begin soon.

“Phase I is complete and everyone loves it,” said Deputy Mayor Joseph Florio.  Florio said construction on the south end of Stuyvesant Avenue, from Morris Ave. to the cannon turnaround near Elmwood, should be complete by ...

DAWN of a New Day: New Treatment Insights Shared at Atlantic Health's 18th Annual 'Stroke Symposium'

MORRISTOWN, NJ - Time is of the essence when it comes to identifying and treating symptoms of stroke and it’s widely accepted that the sooner treatment is provided the better the outcome will be, however new research suggests that all hope isn’t lost for certain types of stroke victims whose symptoms aren’t treated until later in time after last being seen as ...

Porchlight Post - Shedding Light On These Old Homes

May 23, 2018

You bought a new house (congratulations!) and its your first night in the new house. You get cozy and settle in for the night. Your husband wakes up early for work and then so do the kids. Its 5:30 a.m., and your hardwood floors creak so loudly it sounds like someone was trying to break-in. How did you not notice this before you moved in?

Or maybe you’ve been in your house for years and ...

2nd Annual Theater in The Park Returns to Founders Park in South Orange on June 3

The 2nd Annual Theater in The Park is coming to Founders Park on Sunday, June 3, from noon to 4 p.m.

Bring your blankets and chairs, grab some food and fun from one of our vendors and enjoy one or all of the performances by local talent. The event is free and open to everyone who wants to stop in and enjoy some entertainment.

Founders Park is located at 265 Valley St. in South ...

Career Change for Working Moms Presentation at Millburn Library

The Millburn Free Public Library is pleased to offer a program on changing careers for working moms, presented by local career coach Tracey Gutierrez. This program will be held on Thursday, June 14 at 7:00pm.

Are you looking for a career change that better fits the lifestyle you want? Do you leave your children every day to slog away at a job you don't enjoy? You CAN escape from an unhappy ...