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Brain Cancer Study Opens at Overlook Medical Center - One of Four Sites in Country

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Kurt Jaeckle, MD, co-director of the Gerald J. Glasser Brain Tumor Center at Overlook Medical Center, and medical director of the Atlantic Center for Research, is leading a phase III study of novel drug VAL-083, which has already shown promise in Glioblastoma and other cancers.  The study is for patients whose glioblastoma multiforme or gliosarcoma has progressed during or after treatment with the standard of care chemo-radiation therapy. Other study locations are: Kaiser Permanente Los Angeles Medical Center; University of California, San Francisco; and Dent Neurosciences Research Center, Amherst, NY.

“Glioblastoma is very difficult to treat, and I am encouraged by previously reported results with VAL-083,” said Dr. Jaeckle.  “I am also happy that some of the most innovative pharmaceutical companies are looking to Atlantic Health System when they seek to test new types of treatments for brain tumors. The availability of this and other neuro-oncology clinical trials provides a benefit to our patients, and gives me hope for the future.”

Glioblastoma is the most common and most aggressive type of brain cancer, with typical survival of 14-20 months for newly diagnosed patients.  Standard treatment includes surgery to remove as much of the tumor as is safely possible, followed by radiation therapy and chemotherapy with temozolomide.  Nearly all glioblastoma patients will relapse.  Gliosarcoma, which is also being studied in this clinical trial, is a rare and equally aggressive form of glioblastoma. 

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VAL-083 is a first-in-class small molecule chemotherapy drug.  This means that the molecular structure of VAL-083 is not similar in chemical structure (an analogue) or derivative of other small molecule chemotherapeutics approved for the treatment of cancer.  VAL-083 is unique in that it has been shown to overcome cancer cells’ resistance to MGMT, a DNA-repair mechanism that causes recurrent glioblastoma to resist treatment with temozolomide.  Many glioblastoma tumors express large amounts of MGMT, making them difficult to treat with currently available chemotherapies.

According to DelMar Pharmaceuticals, VAL-083 has been assessed in 42 Phase I and Phase II clinical trials sponsored by the National Cancer Institute as a treatment against various cancers. Published pre-clinical and clinical data suggest that VAL-083 may be active against a range of tumor types, including lung, brain, cervical, ovarian tumors and hematologic (blood) cancers.  Earlier clinical trials have shown that VAL-083 is comparable or superior to other chemotherapies in treating glioblastoma.

To learn more about study inclusion and exclusion criteria, go to the Atlantic Center for Research: research.atlantichealth.org/VAL_083.

About the Gerald J. Glasser Brain Tumor Center

Specialists at the Gerald J. Glasser Brain Tumor Center treat a variety of brain tumors and related conditions, including acoustic neuromas and schwannomas; anaplastic astrocytomas, oligodendrogliomas and low-grade gliomas; brain, epidural and leptomeningeal metastases; ependymomas; glioblastomas; low-grade astrocytomas; lymphomas; meningiomas; medulloblastomas; peripheral nerve, pineal and pituitary tumors; rare glial and neuronal tumors; sarcomas; and spinal cord tumors. The center features a multidisciplinary panel of experts who specialize in neurosurgery, skull base surgery, neuroradiology, radiation oncology, neuro-oncology, medical oncology, neurology, neuropathology and social work. Overlook Medical Center also has the largest CyberKnife® program in the tri-state area for the treatment of brain tumors. The brain tumor center recently moved into its own space on the main level of Overlook Medical Center, in order to foster an optimal, convenient patient-centered experience.

Dr. Jaeckle sees patients at the Gerald J. Glasser Brain Tumor Center of Overlook Medical Center’s Atlantic Neuroscience Institute and Carol G. Simon Cancer Center, 99 Beauvoir Avenue, Summit, NJ. He and other members of the Gerald J. Glasser Brain Tumor Center can be reached at (908) 516-2941. For more information on this clinical trial or other studies, please call the Atlantic Center for Research at (973) 971-5235.

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Maplewood Police Blotter - Thefts from Unsecured Vehicles Reported

May 25, 2018

May 14 - Theft from Auto; During the overnight hours electronics and coins were removed from two unsecured vehicles parked on Lexington Ave.

May 14 - Theft from Auto; During the overnight hours a wallet and other items were removed from two unsecured vehicles parked in a driveway on Princeton St.

May 18 - Burglary; During the daytime hours a home on the 500 block of Richmond ...

South Orange Police Blotter - Two Arrested and Charged with DWI

South Orange Police Blotter as of May 24

Theft of Bicycle - A South Orange resident reported that sometime between 5:45 a.m. and 1:20 p.m., Tuesday, May 22, actor(s) unknown stole his black & white Gary Fisher mountain bike, which had been locked and secured to the bicycle rack under the main train station.

Commercial Burglaries - Two adjacent West South Orange ...

Maplewood and South Orange Events for Memorial Day Weekend - and What's Closed

May 24, 2018

MAPLEWOOD AND SOUTH ORANGE, NJ - There is a lot going on in the two towns this Memorial Day weekend, as well as some closures on Monday in observance of Memorial Day.

SATURDAY, MAY 26

The Maplewood Community Pool opens at noon for the 2018 season. (The South Orange Community Pool is opening June 2, details here.)

Downtown After Sundown presents "Jazz on ...

Maplewood Community Pool Scheduled to Open on Saturday, May 26

MAPLEWOOD, NJ -- The Maplewood Community Pool is scheduled to open this Saturday, May 26, and be open Saturday, Sunday, and Monday (Memorial Day) from noon to 6 p.m., according to an update from the Maplewood Recreation Department.

For those who wish to join the pool, registration can be done in person at the Recreation Department (574 Valley St.) on weekdays from 9 a.m. to ...

Upcoming Events

Sun, May 27, 11:00 AM

The Ethical Culture Society of Essex County, Maplewood

Memorial Day Colloquy: What We Honor and How We ...

Other

Thu, May 31, 5:30 PM

Arden Courts, West Orange

Living with Alzheimer's for the Middle Stage ...

Education Health & Wellness

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Thu, May 31, 7:00 PM

Par 440 Restaurant & Lounge, Millburn

Rocky Marciano, Jr. Unveils Rocky Marciano Wine ...

Arts & Entertainment Food & Drink

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Fri, June 1, 7:00 PM

Par 440 Restaurant & Lounge, Short Hills

The Extra Rich In Class Dinner Show with E.R.I.C.

Arts & Entertainment Food & Drink

SURVIVING A STROKE: Quick Medical Response Gives Mom Her Life Back

Carotid artery dissection. It’s one of the most common causes of stroke in younger adults.

And while you might not associate the word “stroke” with younger patients, the condition – if not treated immediately – could lead to paralysis and even death.

Lindsey Singh can attest to the importance of immediacy. The 31-year-old mother of two from Flanders experienced ...

Domestic Violence Prevention Advocates SOFIA Honors Local Leaders During Annual Gala

May 24, 2018

WEST ORANGE, NJ - More than 200 supporters gathered at the Wilshire Grand Hotel in West Orange on Sunday to celebrate 9 years since the founding of S.O.F.I.A (Start out Fresh Intervention Advocates).

Founder Cynthia Walker and the gala committee of Chaz Moore, Kelly Moore, Lisa Boyd and Ida Walker pulled out all stops incorporating the color of purple throughout the venue for ...

Millburn Parents and Students Come Out to Board of Education Meeting to Push for Teacher Contract Resolution

MILLBURN, NJ -- Millburn school district parents and student representatives urged the Board of Education on Monday to quickly settle ongoing contract negotiations with the Millburn Education Association.

The prolonged deadlock between the board and the teachers’ union has lasted nearly a year has been bad for teacher morale and was beginning to take a toll on students, particularly at ...

A.J. Perri Helping Veterans in Need - Again

May 24, 2018

TINTON FALLS, NJ – A.J. Perri is back helping veterans in need – this time launching a search for veterans and their families through a partnership with ABC-TV.

As part of the A.J. Perri Cares Program, a lucky New Jersey veteran and their family will receive air conditioning/heating relief this summer.

"They fought for our country, and their families sacrificed," said ...

Vehicular Homicide Charges for Driver of Paramus School Bus

MORRISTOWN, NJ - The driver of a school bus involved in a crash on Route 80 last week that killed two people faces two counts of second-degree vehicular homicide/death by auto, it was announced today.

The driver, Hudy Muldrow, 77, of Woodland Park, attempted to make an illegal U-Turn on the highway in an attempt to find his way to Waterloo Village, the planned destination of the bus that was ...

Free Adult Health Screenings at the Maplewood Library on Wednesday, June 6

May 26, 2018

Free Adult Health Screenings    

Wednesday, June 6           

10:30 am-noon at Main Library 

Blood pressure and carotid bruit screening, medication, weight & health counseling, Open to Maplewood residents 18 and older. Staffed by Maplewood Health Dept. nurses. Drop in.

Weekly Specials at Ashley Marketplace - and a Memorial Day Coupon

Shop Ashley Marketplace & Cafe for your everyday needs!

This week's specials are:          

Wheatgrass Shot  $2.99 (Bakery)
Corn 4/$2.99
Roasted Vegetables $7.99lb(Prep Food)
Boar’s Head Beef Pastrami  10.99lb(Deli)
Cooked Shrimp $17.99(Ashley Fish Market)
Cave Aged Gruyere $16.99lb ...

Rocky Marciano, Jr. Unveils Rocky Marciano Wine at Par 440 on May 31

A Champion’s Commitment. The Taste of Excellence.

The wine will be unveiled at an invitation only event at PAR 440 Restaurant and Lounge in Short Hills, NJ, attended by Rocky Marciano, Jr.   

PAR 440 is the perfect venue for hosting the unveiling of the wine. The restaurant built by Mario LaVecchia, is decidedly modern with old school charm, and features amazing ...