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Atlantic Health System Cancer Care First in World to Begin Clinical Trial of Novel Virus-Based Immunotherapy for Late-Stage Melanoma; First Patient Enrolled

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Dr. Eric Whitman Leads Study of Experimental Drug That Uses Cold Virus to Disable Cancer Cells in Patients Who Have Not Responded to Other Treatments

Morristown, NJ Atlantic Health System Cancer Care is the first oncology institution in the world to sign on to, and to enroll the first patient in, a multicenter Phase IIa clinical trial of OBP-301 (Telomelysin®), a virus-based immunotherapy for late-stage melanoma that has not responded to other treatments. 

This leading-edge experimental therapy, which is under development by Japanese biotechnology company Oncolys BioPharma, uses the common cold virus to modify a gene that can selectively replicate in, and destroy, cancer cells. The study protocol was approved by the U.S. Food and Drug Administration (FDA) in June.

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The clinical trial is being led locally by Eric D. Whitman, MD, FACS, medical director of Atlantic Health System Cancer Care and director of the Carol G. Simon Cancer Center’s Atlantic Melanoma Center at Morristown Medical Center and Overlook Medical Center.

“This targeted immunotherapy holds great promise for improving survival rates in patients with unresectable and metastatic melanoma,” said Dr. Whitman.  “We are proud to have been chosen as the first site for this leading edge clinical trial, and happy to be able to offer a wide range of the latest established and experimental treatments to our patients.”

Melanoma, the most serious form of skin cancer, affects more than 50,000 people each year. Although the chances of having melanoma increase with age, the number of cases among young adults is rising every year. Melanoma can have serious health consequences and may even be fatal.

The OBP-301 trial is a multicenter, Phase IIa study to evaluate how melanoma tumors respond to injection of this drug in patients with Stage III and Stage IV melanoma -- that is, to determine how much the drug shrinks or destroys tumors after it is injected into them.  The study, which will also look at potential side effects, is “open label,” meaning that all participants in the study will receive OBP-301. 

OBP-301 is a type of virus known as an adenovirus. Adenoviruses are common in nature and when they multiply in normal human cells they may cause infections that result in symptoms like those of the common cold or the flu.  OBP-301 has been genetically changed from the original virus to reproduce in target cancer cells that are emitting a certain signal. As a result of this reproduction, OBP-301 is believed to burst and kill tumor cells.

Study participants will receive multiple injections into their tumors over a period of several weeks.  Blood tests will be done to evaluate the level of virus in patients’ systems, and for immune response monitoring. Dr. Whitman and colleagues will also evaluate how long it takes to get a response and how long responses last, as well as overall survival and progression-free survival rates.

In preclinical studies, Oncolys demonstrated OBP-301’s anti-tumor activity in various types of cancer cells.  A Phase I clinical trial in the U.S. demonstrated the drug’s safety, and showed that it shrank tumors in a majority of study participants, who had a variety of solid tumors.  Additional studies of the drug have been completed, or are underway, in Japan, Korea and Taiwan.

The Atlantic Melanoma Center, a clinical and research center of excellence, is an internationally-recognized program. The center’s multidisciplinary approach-- combining the expertise of board-certified surgeons, medical oncologists, pathologists, radiation oncologists and nurses – treats all forms of melanoma, including those in the skin, mucous membranes and eyes.  Patients receive the latest medical treatments, and when needed, melanoma surgery is also available. 

For more information on the OBP-301 clinical trial or other studies, please call the Atlantic Melanoma Center at 973-971-7111.  

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Sparta

Sparta Police: Speeding Stop Nets Drug Charges for Two Brooklyn Men

June 19, 2018

SPARTA, NJ – Two men from Brooklyn, New York stopped for speeding are facing drug charges.  On June 16 around 11 a.m. Sparta Police Officer Thomas Herd pulled over a grey Toyota Rav4 driven by David Mai, 20 going 95 MPH in a 55 MPH zone, police said.

When Herd spoke with the Mai, the officer smelled marijuana in the car. Mai said he had pot in his backpack.  Sparta Police ...

Sparta Police: Wanted Sparta Man Stopped for Speeding

SPARTA, NJ — A Sparta resident was picked up on an active warrant after getting stopped for speeding on Route 181. On June 16 around 1:35 a.m. Cpl. Marc Rubino stopped John Clark, 51 in his black Ford pickup driving 60 in a 45 MPH zone, police report.

Clark was not able to show the officer his license but gave his personal information. Rubino found Clark’s license had expired and ...

Sparta Police: Wanted Man Picked Up in Speeding Stop, Gets Drug Charges

SPARTA, NJ — A Newark man was picked up when the car in which he was riding was stopped for speeding. On June 8 around 11:50 a.m. Sparta Police Officer Thomas Herd pulled over Tashiana Martin, 27, of West Orange for speeding, police report.

When Herd spoke with Martin he smelled marijuana in the car. Herd also saw that passenger Ibenabdul Harden, 28, was not wearing a seat belt. When the ...

The Power of Positive Engagement

June 17, 2018

To the Editor:

I wanted to share this letter from Laurie Beacham, Media Director for NJ 11th for Change, about the notable increase in voter turnout and citizens deciding to run in the recent primary election:

"The 11th Congressional District has a lot to be proud of. In the June 5th primaries, voter turnout climbed from almost 33,000 in 2014 to over 86,000. Democratic ...

Again, Oroho, Space and Wirths Get It Wrong

On Wednesday, June 13th, a series of gun violence prevention bills were signed into law by Governor Murphy. These bills will strengthen our already strong gun laws in New Jersey and none of these new laws infringe on anyone’s right to keep and bear arms.   

Unfortunately, Senator Oroho and Assemblymen, Space and Wirths our Legislative District 24 representatives voted NO to a ...

Upcoming Events

Thu, June 21, 2:00 PM

Van Kirk Homestead Museum, Sparta

Summer Afternoon Garden Soiree

Home & Garden

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Sat, June 23, 9:00 AM

Sparta Health and Wellness parking lot, Sparta

Sparta Farmers Market

Sat, June 23, 10:00 AM

CASA of Morris and Sussex Counties, Morristown

CASA Information Session

Sun, June 24, 1:00 PM

Van Kirk Homestead Museum, Sparta

Life Along the Wallkil River

Education

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Mon, June 25, 5:30 PM

Mohawk Avenue School, Sparta

Sparta Board of Education Meeting UPDATED

Education

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Sat, June 30, 9:00 AM

Sparta Health and Wellness parking lot, Sparta

Sparta Farmers Market

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Sat, July 7, 9:00 AM

Sparta Health and Wellness parking lot, Sparta

Sparta Farmers Market

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Sun, July 8, 1:00 PM

Van Kirk Homestead Museum, Sparta

Sussex County Views: The Art of Toni Chaplin

Home & Garden

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Sun, July 8, 1:00 PM

Van Kirk Homestead Museum, Sparta

Sussex County Views: The Art of Toni Chaplin

Arts & Entertainment

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Sat, July 14, 9:00 AM

Sparta Health and Wellness parking lot, Sparta

Sparta Farmers Market

Sussex Stags Football Team to Hold Fourth Annual Golf Outing

June 16, 2018

NEWTON, NJ—The Sussex County Stags will be holding their fourth annual gold outing on Saturday June 23.

Arrival time is 11:30 a.m. at the Minebrook Golf Club located at 500 Schooleys Mountain Road in Hackettstown. Golfing will begin at 1 p.m. and tickets can be purchased online at www.sussexstags.com.

Tickets are $125 per person and include the following: golfing, the cart, an all you ...

Update: Police Break Up Fight Involving 40-50 People at Bridgewater Commons Mall

June 15, 2018

BRIDGEWATER, NJ — No injuries have been reported in an incident that shut down Bridgewater Commons Mall Thursday evening after a fight involving a crowd of 40-50 people.

Police are still investigating unconfirmed reports of shots being fired, according to the Somerset County Prosecutor's Office.

The mall is closed for the evening as the investigation continues.

Somerset County ...

Why Buying a Home is Better Than Renting

People often ask if now is a good time to buy a home in New Jersey, but nobody ever asks whether or not it’s a good time to rent. Regardless, Team Nest Builder wants to make certain that everyone understands that now is NOT a good time to rent.

The Census Bureau recently released their 2018 first quarter median rent numbers. This graph from their report shows rent increases from 1988 ...

5 Fab Father's Day Happenings in Sussex & Morris Counties

Father’s Day hits this Sunday--what do YOU have planned? Team Nest Builder offers a slew of Father’s Day fun in Morris and Sussex County. Read on and surprise Dad with cool activities! (Be sure to check if registration is required prior to showing up!)

Alstede Farms' Father's Day Brunch – Chester

From 9am-noon, take a scenic hayride to a brunch buffet that offers ...

Don't Miss Sunday's OPEN HOUSE for 4BR Sparta Mountain Beauty

Perched handsomely on an acre in the beautiful SpartaMountain community, 28 Waters Edgeoffers a 4BR 2.5 Bathroom home with space and style. Come see for yourself this Sunday, June 17th, from 1-3pm at our OPEN HOUSE!

Located in the prestigious Sparta Mountain Reserve, this large, beautiful center hall colonial with open floor plan has a nice, level play yard with direct ...

Days on The Housing Market Drops to New Low

According to recently released data from the National Association of Realtors (NAR), the median number of days that a home spent on the market hit a new low of 26 days in April, as 57% of homes remained on the market for under a month.

NAR’s Chief Economist, Lawrence Yun, opined,

“What is available for sale is going under contract at a rapid pace. Since NAR began tracking this ...

Pass It Along Triathlon

Tri-something new this July and sign up for the Pass It Along Triathlon!

The 9th annual Pass It Along Triathlon will take place on Saturday, July 28, 2018, at the Lake Mohawk Country Club. This triathlon features two USAT-certified courses - Olympic and Sprint. This triathlon has become a Sparta tradition and everyone is welcome to attend to cheer on athletes and be a part of the ...

Welcome to the Pass It Along Column!

This is the first in a weekly series of columns which will focus on news, events, announcements, and opportunities from Pass It Along. Please check back next week to see what’s happening!

Welcome to Pass It Along's TAPinto column! We are so excited to partner with TAPinto Sparta to share news, highlights and opportunities with you to get involved with Pass It Along!

What is ...

AtlantiCast

AtlantiCast: Episode 16

Summer is in the air, and the latest episode of AtlantiCast is ready to help you enjoy some fun outdoors while staying safe! This week’s episode opens with tips for sunscreen usage from Atlantic Health System’s Chief Medical and Academic Officer, Dr. Jan Schwarz-Miller. You’ll also learn about how Atlantic Health System is advancing the future of health care through ...

June 13 Sussex County Board of Chosen Freeholders meeting

NEWTON, NJ - The June 13 Sussex County Board of Chosen Freeholders meeting video.

 

Summer Hockey Programs at Skylands: 3v3, U8 and Beginner Hockey Camp

June 19, 2018

Skylands U8 Cross Ice Challenge League

Skylands Cross Ice Challenge League is an intermediate league for kids ages 8 and under. Emphasis on fun, skill progression, and player development, it de-emphasizes stressful, high-pressure, game scenarios and ultra-competitive play. It's focus is more on individual skating, player skills & puck touches
One practice per week ...